Articles liés à Insulin-Like Growth Factors and Cancer: From Basic...

Insulin-Like Growth Factors and Cancer: From Basic Biology to Therapeutics - Couverture rigide

Livre 69 sur 96: Cancer Drug Discovery and Development
 
9781461405979: Insulin-Like Growth Factors and Cancer: From Basic Biology to Therapeutics

Synopsis

The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.

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À propos de la quatrième de couverture

The insulin-like growth factor system has been shown to play a critical role in cancer development and progression. Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics, specifically brings these aspects to the reader. The volume covers the epidemiological aspects of the relationships between circulating insulin and IGF-1 levels and the risk for cancer and cancer-related mortality and in particularly in disease states such as obesity and Type 2 diabetes. It then addresses the basic biology of the system and how the ligands, receptors and IGF-binding proteins affect cancer cell biology and cancer progression. Finally, it discusses the therapeutic potential of inhibiting the receptors using various newly discovered monoclonal antibodies and tyrosine kinase inhibitors that are in preclinical and clinical trials.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.