Molecular Genetics of Pancreatic Cancer - Couverture rigide

Couverture rigide

ISBN 10 : 1461465486 ISBN 13 : 9781461465485

Editeur : Springer-Verlag New York Inc., 2013

Synopsis

Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients.

In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.

Détails de l'édition

• Éditeur: Springer-Verlag New York Inc.
• Date d'édition: 2013
• Langue: anglais
• ISBN 10: 1461465486
• ISBN 13: 9781461465485
• Reliure: Relié
• Nombre de pages: 240
• Éditeur: Simeone Diane M., Maitra Anirban
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne