Ryanodine Receptors: Structure, function and dysfunction in clinical disease - Couverture souple
Livre 110 sur 248: Developments in Cardiovascular Medicine
Synopsis
Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology. The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease. There are interesting new developments in the control of ryanodine receptors by accessory proteins, the latest of which is the proposed role of leaky RyR channels in causing delayed after depolarizations, a cause of lethal ventricular arrhythmias. The series of reviews in Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease will bring anyone rapidly up to speed in current progress in the field, as well as highlight remaining questions.
David E. Clapham, MD, PhD
Professor of Neurobiology and Pediatrics
Harvard Medical School
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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254)
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Ryanodine Receptors
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor.'In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology.' David E. Clapham, MD, PhDProfessor of Neurobiology and PediatricsHarvard Medical SchoolDr. Xander H.T. Wehrens received his M.D. and Ph.D. degrees from Maastricht University in the Netherlands. His research has mainly concentrated on molecular mechanisms of cardiac arrhythmias, in particular in the setting of inherited arrhythmogenic syndromes and congestive heart failure. This work has led to the development of novel anti-arrhythmic therapies. He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University.Dr. Andrew R. Marks is the Chair and Professor of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons. Dr. Marks' research has focused on understanding how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems, and on the regulation of vascular smooth muscle proliferation and migration. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction that have lead to the discovery of molecular defects that contribute to heart failure and fatal cardiac arrhythmias. 356 pp. Englisch. N° de réf. du vendeur 9781461498407
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Most current publication devoted solely to the major intracellular calcium-release channel, the ryanodine receptor Will quickly bring anyone interested in ryanodine receptors up to speed with its brief but informative chapters Drs. Xande. N° de réf. du vendeur 11466270
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Ryanodine Receptors
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Springer US, Springer New York Dez 2014, 2014
ISBN 10 : 1461498406
ISBN 13 : 9781461498407
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology. The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease. There are interesting new developments in the control of ryanodine receptors by accessory proteins, the latest of which is the proposed role of leaky RyR channels in causing delayed after depolarizations, a cause of lethal ventricular arrhythmias. The series of reviews in Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease will bring anyone rapidly up to speed in current progress in the field, as well as highlight remaining questions.David E. Clapham, MD, PhDProfessor of Neurobiology and PediatricsHarvard Medical SchoolSpringer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 356 pp. Englisch. N° de réf. du vendeur 9781461498407
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Ryanodine Receptors : Structure, function and dysfunction in clinical disease
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Drs. Xander Wehrens and Andrew Marks have gathered the collected wisdom of scientists that have devoted their working lives to the study of ryanodine receptors. In this series of brief, but informative, chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology. The book ends with several chapters on mutations in the receptor that causes disease and their role in adaptation to disease. There are interesting new developments in the control of ryanodine receptors by accessory proteins, the latest of which is the proposed role of leaky RyR channels in causing delayed after depolarizations, a cause of lethal ventricular arrhythmias. The series of reviews in Ryanodine Receptors: Structure, Function and Dysfunction in Clinical Disease will bring anyone rapidly up to speed in current progress in the field, as well as highlight remaining questions.David E. Clapham, MD, PhDProfessor of Neurobiology and PediatricsHarvard Medical School. N° de réf. du vendeur 9781461498407
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Ryanodine Receptors: Structure, function and dysfunction in clinical disease (Developments in Cardiovascular Medicine, 254)
Edité par
Springer, 2014
ISBN 10 : 1461498406
ISBN 13 : 9781461498407
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