Synopsis
1 Structure and Function Relationships among Synthetic Enkephalin Analogues.- 1. Introduction.- 2. Opiate Activity of Enkephalins and ?-Endorphin.- 3. Design and Synthesis of Enkephalin Analogues with Improved Opioid Activity.- 4. Modification at the N Terminus.- 5. Modification at the C Terminus.- 6. Conclusions.- Discussion.- References.- 2 Secondary Structure - Function Relationships in ?-Endorphin: A Proposed Model of the Biologically Active Conformation.- 1. Introduction.- 2. Circular Dichroism Studies.- 3. Predictive Analysis of the Secondary Structure.- 4. Correlation between the Solution Conformation and Biological Activity.- References.- 3 Studies on the Conformation of Neuropeptides.- 1. Introduction.- 2. Material and Methods.- 3. ACTH.- 4. Angiotensin II.- 5. Thyroliberin.- 6. Conclusion.- Discussion.- References.- 4 The Search for the Active Center of the Gonadotropins.- 1. Introduction.- 2. Methods in Peptide Synthesis.- 3. Testing of Inhibitory Peptides.- 4. Discussion.- 5. Summary.- 6. Projections for the Future.- Discussion.- References.- 5 Hormonal Antagonistic Properties of Deglycosylated Pituitary Lutropin.- 1. Introduction.- 2. Preparation of Deglycosylated LH.- 3. Biological Properties of DG-LH.- 4. Concluding Comments.- References.- 6 Hormonal Regulation of and Ionic Requirements for in Vitro Release of Hypothalamic Peptides.- 1. Introduction.- 2. Effects of Neurotransmitters or Neuropeptides on Hypothalamic Hormone Release in Vitro.- 3. Interaction of Opiates with LH-RH and SRIF Release.- 4. Ionic Requirements of Neuropeptide Release.- 5. Are Neuropeptide-Neurotransmitter Interactions Coupled with Ionic Channels?.- 6. Hormonal Effect on Neuropeptide Release in Vitro.- 7. Conclusion.- References.- 7 In Vitro Release of Luteinizing Hormone-Releasing Hormone: Influence of Estrogen and a Mammary Carcinogen.- 1. Introduction.- 2. Methods.- 3. Results.- 4. Discussion.- Discussion.- References.- 8 Mode of Opioid and Catecholamine Involvement in Regulating LH Secretion.- 1. Introduction.- 2. Effects of Opiates on LH Release.- 3. Effects of Opiate Receptor Antagonists on Pituitary LH Release.- 4. Effects of Estrogen on LH Release Induced by Naloxone.- 5. Mode of Opiate Involvement in Pituitary LH Release.- 6. Site(s) of Opiate Modulation of LH Release.- 7. Summary.- Discussion.- References.- 9 Stress, Corticoliberin (CRF), and Glucocorticoids in the Regulations of ACTH Release.- 1. Introduction.- 2. ACTH-Secreting Cells.- 3. The Nature of CRF.- 4. The Site of CRF Release.- 5. The Location of CRF-Producing Cells.- 6. Afferent Pathways of Stressful Stimuli.- 7. Feedback Regulation of ACTH Secretion.- References.- 10 The Role of Steroid Receptors in the Regulation and Integration of Steroid and Peptide Hormone Actions in Common Target Cells: Facts and Speculations.- 1. Introduction.- 2. The Basic (Hypothetical) Concepts of the Proposed Model for Integrating the Actions of Steroid and Peptide Hormones in Common Target Cells.- 3. Experimental Facts Supporting the Basic Concepts of the Proposed Model.- 4. Coordination and Integration of Steroid and Peptide Hormone Actions in Common Tar get Cells.- 5. Potentiation.- 6. The Model-Description, Postulates, and Speculations.- 7. Summary and Prospects for the Future.- Discussion.- References.- 11 Effects of Estrogens on Receptor "Nucleotropy" and "Activation".- 1. Introduction.- 2. Subcellular Origins and Properties of Uterine Estradiol Receptors.- 3. Reactions of Uterine Cells to Pulse-Administered Estradiol.- 4. Receptor "Nucleotropy" and "Activation".- 5. Ovarian- and Steroid-Independent Fluctuations of Uterine Estradiol Receptor Action.- 6. The Basic Mechanism of Estradiol Receptor Action.- 7. How to Succeed in Mapping the Steroid-Sensitive Areas of the Brain.- References.- 12 Steroids and Membrane-Associated Events in Neurons and Pituitary Cells.- 1. Introduction.- 2. The Electrophysiological Approach.- 3. Electrophysiological Approach to the Study of Sex Steroid Effect
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