Synopsis
1 Carbon Monoxide and Human Functions.- Background.- Recent Work in our Laboratory.- General Methodology.- Display Experiment.- Digit Span and Arithmetic Tests.- Vigilance Experiment.- Perceptual Tracking Study.- Spatial Perception Study.- Discussion.- Summary.- Acknowledgments.- References.- General Discussion.- 2 The Effect of Carbon Monoxide on Time Perception, Manual Coordination, Inspection, and Arithmetic.- Experimental Method.- Results.- The Effect of CO on the Beard-Wertheim Time Discrimination Test.- The Effect of CO on Ten-Second Estimations.- The Effect of CO on Thirty-Second Estimations.- The Effect of CO on the Marquette Time Estimation Test.- Manual Coordination and Cognitive Tests.- Discussion.- Summary.- References.- General Discussion.- 3 Preliminary Studies of the Effects of Carbon Monoxide on Vigilance in Man.- Method.- Subjects.- Testing Procedure.- Chemical Procedure.- Results.- Discussion.- Summary.- References.- General Discussion.- 4 Carbon Monoxide and Human Performance: A Methodological Exploration.- Method.- Dependent Variables.- General Purpose.- Gas Exposures.- Experiment I. Simultaneous Digit-Processing and Peripheral Detection.- Behavioral Methods.- Practice.- Results.- Experiment II. The Rate Threshold of Blocking.- Results.- Experiment III. Simultaneous Digit-Processing and Double-Jump Detection.- Method.- Results.- Experiment IV. Effects of Carbon Monoxide on Eye Movements and Monitoring Performance.- Method.- Results.- Experiment V. Effects of Carbon Monoxide on Self-Paced Digit Keying.- Practice.- Results.- Concluding Remarks.- Summary.- Acknowledgments.- References.- General Discussion.- 5 The Comparative Effects of Hypoxic and Carbon Monoxide Hypoxia on Behavior.- Procedures.- Hypoxia.- Carbon Monoxide.- References.- General Discussion.- 6 The Application of a Computer-Controlled Time Discrimination Performance to Problems in Behavioral Toxicology.- Methods and Materials.- Subjects.- Behavioral Testing Chamber.- Computer Hardware.- Behavioral Training and Computer Software.- Time Discrimination Thresholds.- Procedure.- Results and Discussion.- Summary.- Effects of Chorpromazine on Time Discrimination.- Background.- Procedure.- Results and Discussion.- Summary.- Effects of Carbon Monoxide on Time Discrimination.- Procedure.- Results and Discussion.- Summary.- Acknowledgments.- References.- General Discussion.- 7 Behavioral Toxicity of Anticholinesterase Agents: Methodological, Neurochemical, and Neuropsychological Aspects.- Materials and Methods.- Subjects.- Measurement of Symptoms.- Avoidance Tests.- Measurement of Enzyme Activity.- Measurement of Brain Acetylcholine Levels.- Drug Treatments.- Acute Anticholinesterase Effects.- Dose-Response Curves and Time Course of Acute Intoxication.- Additional Methodological Considerations: Schedule Effects.- Brain Biochemistry during Acute Intoxication.- Subacute and Chronic Anticholinesterase Effects.- A Summary of Literature Data.- Chronic Treatments and Avoidance Performance.- Repeated Treatments during Avoidance Acquisitions.- Mechanisms Responsible for Tolerance.- Possible Central Actions of Enzyme Reactivations.- Cholinergic Systems and Behavior.- Human Anticholinesterase Intoxication.- General Discussion and Conclusions.- Summary.- Acknowledgments.- References.- General Discussion.- 8 Behavioral Toxicologic Studies of Dieldrin, DDT, and Ruelene in Sheep.- Method.- Selection of Neurotoxicants.- Experimental Animals.- Selection of Behavioral Tasks.- Sheep Behavior Studies.- Results.- Effect of Dieldrin on Heart Rate and the Extinction of a Conditioned Avoidance Response.- Effect of Dieldrin on the Performance of a Detour Maze Task.- Effect of Dieldrin on the Relearning of a Visual Discrimination.- Effect of Dieldrin on the Performance of an Auditory Signal Detection Task.- Other Behavioral Toxicologic Studies with Sheep as Subjects.- Discussion.- Summary.- Acknowledgments.- References.- General Discussion.- 9 Use of Behavioral Techniques in the
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