Articles liés à Contemporary Topics in Immunochemistry: Volume 1
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Synopsis
The Relationship Between Antigenic Structure and Immune Specificity.- I. Introduction.- II. Antigens.- A. Poly-?-D-Glutamyl Capsule of Bacillus anthraces.- B. Adrenocorticotropic Hormone (ACTH).- C. Angiotensin.- D. Bradykinin.- E. Gastrin.- F. Glucagon.- G. Ferredoxin.- H. Insulin.- I. Cytochrome c.- J. Ribonuclease.- K. Lysozyme.- L. Myoglobin.- M. Hemoglobin.- N. Tobacco Mosaic Virus and Its Protein Subunit.- III. Discussion.- A. Reaction with Circulating Antibodies.- B. Specificity of Cellular Immune Reactions.- IV. Concluding Remarks.- References.- Human Histocompatibility Antigens.- I. Introduction.- II. Extraction of Histocompatibility Antigens.- III. Solubilization and Purification of HL-A Antigens.- A. Antigen Source Material.- B. KCl Extraction Technique.- C. Purification with Polyacrylamide Gel Electrophoresis.- IV. Biological Evaluation of Soluble HL-A Antigens.- V. Chemical Characterization of HL-A Antigens.- A. Antigens Prepared from Spleen Cells.- B. HL-A Antigens from Lymphocytes in Culture.- VI. Chemical Nature of HL-A Alloantigens.- VII. Summary.- Acknowledgment.- References.- Bacterial Flagellin as an Antigen and Immunogen.- I. Introduction.- II. Properties of Flagellin from Salmonella Organisms.- A. Physical and Chemical Properties.- B. Antigenic Properties.- III. Degradation and Modification of Flagellin.- A. Antigenic Properties of Fragments Released from Flagellin.- B. Antigenic Properties of Chemically Modified Flagellin.- IV. In Vivo Immunogenicity of Flagellin and Its Derivatives.- A. Immunogenicity of Flagellin and Polymerized Flagellin.- B. Immunogenicity of Fragmented Flagellin.- C. Immunogenicity of Chemically Modified Flagellin.- V. In Vivo Localization Patterns of Flagellin and Its Derivatives.- VI. In Vitro Behavior of Flagellin and Its Derivatives.- A. Induction of Immune Responses.- B. Reaction Between Antigen and Lymphocytes.- VII. Antigen as a Regulator of Cell Behavior.- VIII. Discussion and Conclusions.- References.- The Transfer of Immunity with Macrophage RNA.- I. Introduction.- II. The Heightened Immunogenicity of Antigens Associated with Macrophages.- A. Immune Responses of Fractionated Cell Populations.- B. Retention and Localization of Antigen by Macrophages.- III. RNA-Antigen Complexes.- A. Assessment of the Requirement for Macrophages.- B. Assessment of the Existence of Antigen-Specific RNAs.- C. Assessment of the Requirement for an Enzyme.- D. Relationship Between the Capacity to Complex with RNA and Immunogenicity.- E. The Nature of the RNA-Antigen Chemical Bond.- F. Are RNA-Antigen Complexes Laboratory Artifacts?.- IV. The Transfer of Cellular Immunity with RNA.- V. Informational RNA.- VI. Conclusions.- Acknowledgment.- References.- Relationship of Events at the Lymphocyte Cell Surface to Gene Expression: Approaches to the Problem.- I. Introduction.- II. General Properties of Continuously Growing Cultured Human Lymphocytes.- III. Control of Synthesis of Membrane-Associated Immunoglobulin.- A. Quantitative Aspects.- B. Half-Disappearance of M-Ig in Logarithmically Growing Cells Treated with Inhibitors of Protein Synthesis.- C. Amount and Half-Disappearance of M-Ig and Cytoplasmic Ig in Synchronized "G0" Cells.- D. Half-Disappearance of M-Ig and Cytoplasmic Ig in Logarithmically Growing Cells Treated With Actinomycin D.- IV. Molecular Events During the Rest to Proliferation Transition in Lymphocytes.- A. Synchronization of Cultured Lymphocytes.- B. Phenotypic Expression in Stationary Phase ("G0") and Logarithmically Growing Cells.- C. Polypeptide Synthesis in the "G0" to G1 Transition.- D. Perturbations Using Actinomycin D and Cyclic AMP.- V. Studies on the "Linkage" Between the Plasma Membrane and Cellular Genes.- A. Nature of Cytoplasmic DNA.- B. Association of DNA with Cytoplasmic Membranes.- C. Synthesis of Membrane-Associated DNA in Synchronized Cells.- D. Electron Microscopic Studies of Plasma Membrane-Associated DNA.- VI. Summary and Prospects for the Future.- Acknowledgme
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