Intracellular Messengers - Couverture souple

Couverture souple

ISBN 10 : 1489940278 ISBN 13 : 9781489940278

Editeur : Humana, 2013

Synopsis

Despite the success of earlier Neuromethads volumes, I was initially reluctant to edit a further volume because my own - search is concerned with nonneural tissues. I changed my mind for two simple reasons. First, though the sheer diversity of ext- cellular signal molecules is staggering, still more impressive is the remarkably small number of transmembrane signaling processes they recruit- their receptors either have integral ion channels or enzyme activities, or else they catalytically activate G proteins. Likewise, when we look to the final intracellular t- gets of these signaling pathways, they are stucturally diverse, but again there are common themes: the response may either be the gating of an ion channel, or else the phosphorylation of a target protein. Such conservation of signaling mechanisms is both impressive and convenient, and provides my justification for asking authors with interests in diverse tissues to contribute their methodological expertise to this volume. Second, I think it would be difficult to overestimate the extent to which our understanding of intracellular signaling has been transformed by new and improved methodology. Thus, simple methods for measuring inositol phosphates have revealed the profound and widespread importance of the ph- phoinositide pathways, the techniques of contemporary - lecular biology have provided unrivaled opportunities to relate structure and function, and the complex spatial and t- poral characteristics of intracellular signaling pathways were barely imaginable before the introduction of fluorescent indi- tors and single cell-imaging technology.

A propos du livre

Présentation de l'éditeur

This important new reference work offers an outstanding collection of articles devoted to the discussion of "intracellular messengers" Extracellular stimuli (first messengers) bind to receptors on the plasma membrane of cells to trigger changes in the concentration of intracellular messengers (second messengers) which leads, in turn, to changes in cellular activity. However, the intracellular activities of so called "third messengers" may also be involved complicating the concept of a rigid sequence of events between receptor and response. The preference for the term "intracellular messengers" and, hence, the title of this volume, recognizes that a complex web of interactions between intercellular messengers determines the concentrations and ultimate effects of each.

Détails de l'édition

• Éditeur: Humana
• Date d'édition: 2013
• Langue: anglais
• ISBN 10: 1489940278
• ISBN 13: 9781489940278
• Reliure: Broché
• Nombre de pages: 604
• Éditeur: Boulton Alan A., Baker Glen B., Taylor Colin W.
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne