Targeting the Wnt Pathway in Cancer - Couverture souple

9781489981646: Targeting the Wnt Pathway in Cancer

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ISBN 10 : 1489981640 ISBN 13 : 9781489981646

Editeur : Springer, 2014

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Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

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�diteur: Springer
Date d'�dition: 2014
Langue: anglais
ISBN 10: 1489981640
ISBN 13: 9781489981646
Reliure: Broch�
Nombre de pages: 252
�diteur: Goss Kathleen H., Kahn Michael
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Targeting the Wnt Pathway in Cancer (eng)

Goss, Kathleen H.

Edit� par Springer, 2014

ISBN 10 : 1489981640 ISBN 13 : 9781489981646

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Targeting the Wnt Pathway in Cancer

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Targeting the Wnt Pathway in Cancer

Michael Kahn

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway. 252 pp. Englisch. N� de r�f. du vendeur 9781489981646

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Targeting the Wnt Pathway in Cancer

Goss, Kathleen H.|Kahn, Michael

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Provides an overview of the Wnt pathway as a therapeutic target for cancerDiscusses the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathwayIn-depth look at the Wnt pathway by recognized leaders in. N� de r�f. du vendeur 4212745

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Targeting the Wnt Pathway in Cancer

Kathleen H. Goss (u. a.)

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Targeting the Wnt Pathway in Cancer

Michael Kahn

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of �-catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 252 pp. Englisch. N� de r�f. du vendeur 9781489981646

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Targeting the Wnt Pathway in Cancer

Michael Kahn

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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway. N� de r�f. du vendeur 9781489981646

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