Extrasynaptic GABAA Receptors - Couverture rigide

Livre 20 sur 29: The Receptors

Errington

9781493914258: Extrasynaptic GABAA Receptors

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1) Chapter 1: A brief introduction to extrasynaptic GABAA receptors and 'tonic' GABAA receptor mediated inhibition in physiology and disease - Adam C Errington

2) Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation - Jean-Marc Fritschy and Patrizia Panzanelli

3) Biophysical properties of recombinant y2 and d subunit containing GABAa receptors - Robert L MacDonald and Emmanueal J Botzolakis

4) The pharmacology of extrasynaptic GABAa receptors - Keith A Wafford

5) Neurosteroids and extrasynaptic GABAa receptors - William M Connelly

6) Sources of GABA that activate extrasynaptic GABAa receptors - Damian Bright, Catriona Houston and Stephen Brickley

7) Metabotropic receptor modulation of extrasynaptic GABAa receptors - Giuseppe Digiovanni

8) Extrasynaptic GABAa receptors and tonic inhibition in the spinal cord - Emanuel Loeza-Alcocer, Carmen Andr�s, Justo Aguilar, Ricardo Felix and Rodolfo Delgado-Lezama

9) The role of peri-synaptic GABAa receptors after stroke - Andrew N Clarkson and Mary Chebib

10) The role of extrasynaptic GABAa receptors in focal epilepsy - Matthew C Walker and Ivan Pavlov

11) Gain-of-function of extrasynaptic GABAa receptors in typical absence seizures - Vincenzo Crunelli, Giuseppe Digiovanni, H. Rheinallt Parri and Adam C Errington

12) GABAergic control of the hypothalamic-pituitary adrenal (HPA) axis: role of extrasynaptic GABAa receptors - Jamie Maguire

13) Tonic GABAa receptor mediated inhbition in fr�gil X s�ndrome: A cause of dysfunction or a pathway for cure? - Brandon S Martin and Molly M Huntsman

Les informations fournies dans la section � Synopsis � peuvent faire r�f�rence � une autre �dition de ce titre.

�diteur: Springer
Date d'�dition: 2014
Langue: anglais
ISBN 10: 1493914251
ISBN 13: 9781493914258
Reliure: Reli�
Nombre de pages: 308
Coordonn�es du fabricant: Springer Nature Customer Service Center GmbH
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Extrasynaptic GABAA Receptors (eng)

Errington

Edit� par Springer, 2014

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Extrasynaptic GABAa Receptors

Errington, Adam C. (EDT); Di Giovanni, Giuseppe (EDT); Crunelli, Vincenzo (EDT)

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Extrasynaptic GABAa Receptors

Errington, Adam C. (EDT); Di Giovanni, Giuseppe (EDT); Crunelli, Vincenzo (EDT)

Edit� par Springer, 2014

ISBN 10 : 1493914251 ISBN 13 : 9781493914258

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Extrasynaptic GABAA Receptors

Adam C. Errington

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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed 'tonic' inhibition, has been described. Whereas synaptic GABAA receptors underlie classical 'phasic' GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes. 308 pp. Englisch. N� de r�f. du vendeur 9781493914258

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Extrasynaptic GABAA Receptors

Errington, Adam C.|Di Giovanni, Giuseppe|Crunelli, Vincenzo

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Gebunden. Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. First book to describe tonic inhibition Emphasizes the important role of extrasynaptic GABAA receptors Brings together contributions from leading experts in the fieldGABA is the principal inhibitory neurotransmitter in the CNS and a. N� de r�f. du vendeur 4214123

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Extrasynaptic GABAA Receptors (The Receptors, 27)

Errington

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Extrasynaptic GABAA Receptors

Adam C. Errington

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ISBN 10 : 1493914251 ISBN 13 : 9781493914258

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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed 'tonic' inhibition, has been described. Whereas synaptic GABAA receptors underlie classical 'phasic' GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes. N� de r�f. du vendeur 9781493914258

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Extrasynaptic GABAA Receptors (The Receptors)

Errington

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ISBN 10 : 1493914251 ISBN 13 : 9781493914258

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Extrasynaptic GABAA Receptors

Adam C. Errington

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ISBN 10 : 1493914251 ISBN 13 : 9781493914258

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Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed �tonic� inhibition, has been described. Whereas synaptic GABAA receptors underlie classical �phasic� GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 308 pp. Englisch. N� de r�f. du vendeur 9781493914258

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Etat : Hervorragend. Zustand: Hervorragend | Seiten: 308 | Sprache: Englisch | Produktart: B�cher | GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed �tonic� inhibition, has been described. Whereas synaptic GABAA receptors underlie classical �phasic� GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes. N� de r�f. du vendeur 24808259/1

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