Articles liés à Gadd45 Stress Sensor Genes

Gadd45 Stress Sensor Genes - Couverture souple

Livre 149 sur 544: Advances in Experimental Medicine and Biology
 
9781493953905: Gadd45 Stress Sensor Genes
Couverture souple
ISBN 10 : 1493953907 ISBN 13 : 9781493953905
Editeur : Springer, 2016

Synopsis

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins). These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity. Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus. Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

This book presents a comprehensive picture of the unique global role Gadd45 genes play as stress sensors and the molecular pathways involved.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Springer
Date d'édition
2016
Langue
anglais
ISBN 10 
1493953907
ISBN 13 
9781493953905
Reliure
Broché
Nombre de pages
144
Éditeur
Liebermann Dan A., Hoffman Barbara
Coordonnées du fabricant
non disponible
Personne responsable
CMN Printpool Inh. Mathis Neumann
https://www.also.com/ec/cms5/en_6000/6000/index.jsp

Friedrich-Karl-Str. 9
Hamburg
Allemagne

Autres éditions populaires du même titre

9781461482888: Gadd45 Stress Sensor Genes

Edition présentée

ISBN 10 :  1461482887 ISBN 13 :  9781461482888
Editeur : Springer-Verlag New York Inc., 2013
Couverture rigide