Proteomics for Drug Discovery: Methods and Protocols - Couverture rigide

9781493972005: Proteomics for Drug Discovery: Methods and Protocols

Couverture rigide

ISBN 10 : 1493972006 ISBN 13 : 9781493972005

Editeur : Humana Press Inc., 2017

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1. A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug Candidates

Jason R. Thomas, Scott M. Brittain, Jennifer Lipps, Luis Llamas, Rishi K. Jain, and Markus Schirle

2. Multiplexed Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Quantification of Cancer Signaling Proteins

Yi Chen, Kate J. Fisher, Mark Lloyd, Elizabeth R. Wood, Domenico Coppola, Erin Siegel, David Shibata, Yian A. Chen, and John M. Koomen

3. Monitoring Dynamic Changes of the Cell Surface Glycoproteome by Quantitative Proteomics

Mathias Kalxdorf, Hans Christian Eberl, and Marcus Bantscheff

4. High Resolution Parallel Re

action Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics: An Application to Study the Quantitative Changes Induced by Histone Modifying Enzyme Inhibitors and Activators

Michael J. Sweredoski, Annie Moradian, and Sonja Hess

5. Preparation and Immunoaffinity Depletion of Fresh Frozen Tissue Homogenates for Mass Spectrometry-Based Proteomics in the Context of Drug Target/Biomarker Discovery

DaRue A. Prieto, King C. Chan,2Donald J. Johann, Jr., Xiaoying Ye, Gordon Whitely, and Josip Blonder

6. Target Identification Using Cell Permeable and Cleavable Chloroalkane Derivatized Small Molecules

Jacqui L. Mendez-Johnson, Danette L. Daniels, Marjeta Urh, and Rachel Friedman Ohana

nbsp;

7. Microfluidics-Mass Spectrometry of Protein-Carbohydrate Interactions: Applications to Development of Therapeutics and Biomarker Discovery

Alina D. Zamfir

8. Studying Protein-Protein Interactions by Biotin AP-Tagged Pulldown and LTQ-Orbitrap Mass Spectrometry

Zhongqiu Xie, Yuemeng Jia, and Hui Li

9. Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation

Avital Eisenberg-Lerner, Ifat Regev, and Yifat Merbl

10. Reverse Phase Protein Arrays and Drug Discovery

Kenneth G. Macleod, Bryan Serrels, and Neil O. Carragher

lt;11. Probing Protein Kinase-ATP Interactions Using a Fluorescent ATP Analog

Leslie E.W. LaConte, Sarika Srivastava, and Konark Mukherjee

12. Preparation of Disease-Related Protein Assemblies for Single Particle Electron Microscopy

A. Cameron Varano, Naoe Harafuji, William Dearnaley, Lisa Guay-Woodford, and Deborah F. Kelly

13. Identification of Lipid-Binding Modulators Using the Protein-Lipid Overlay Assay

Tuo-Xian Tang, Wen Xiong, Carla V. Finkielstein, and Daniel G.S. Capelluto

14. Resazurin Live Cell Assay: Setup and Fine-Tuning for Reliable Cytotoxicity

Jos� �. Rodr�guez-Corrales and Jatinder S. J

osan

15. Exploring Protein-Protein Interactions as Drug Targets for Anti-Cancer Therapy with In Silico Workflows

Alexander Goncearenco, Minghui Li, Franco Simonetti, Benjamin A. Shoemaker, and Anna R. Panchenko

16. Method to Identify Silent Codon Mutations that May Alter Peptide Elongation Kinetics and Co-Translational Protein Folding

Ronald Worthington, Elijah Ball, Brentsen Wolf, and Gregory Takacs

17. In Silico Design of Anticancer Peptides

Shailesh Kumar and Hui Li

18. Docking and Virtual Screening in Drug Discovery

Maria Kontoyianni

19. Bioinfo

rmatics Resources for Interpre

Les informations fournies dans la section � Synopsis � peuvent faire r�f�rence � une autre �dition de ce titre.

�diteur: Humana Press Inc.
Date d'�dition: 2017
Langue: anglais
ISBN 10: 1493972006
ISBN 13: 9781493972005
Reliure: Reli�
Num�ro d'�dition: 1
Nombre de pages: 302
�diteur: Lazar Iulia M., Kontoyianni Maria, Lazar Alexandru C.
Coordonn�es du fabricant: non disponible
Personne responsable: non disponible

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9781493984145: Proteomics for Drug Discovery: Methods and Protocols

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ISBN 10 : 1493984144 ISBN 13 : 9781493984145
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Proteomics for Drug Discovery

Lazar, Iulia M.|Kontoyianni, Maria|Lazar, Alexandru C.

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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Includes cutting-edge techniques for the study of drug discovery via proteomicsProvides step-by-step detail essential for reproducible resultsContains key implementation advice from the expertsInc. N� de r�f. du vendeur 150705613

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Proteomics for Drug Discovery: Methods and Protocols (Methods in Molecular Biology, 1647)

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Proteomics for Drug Discovery

Iulia M. Lazar

Edit� par Springer New York Aug 2017, 2017

ISBN 10 : 1493972006 ISBN 13 : 9781493972005

Neuf Couverture rigide

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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book reflects the drug development community's interest in proteomics methods by providing researchers with the necessary knowledge for the implementation of a number of basic experimental and bioinformatics protocols in the drug discovery research laboratory. The focus of the collection is on select protocols and methodologies that address the analysis of post-translational modifications, targeted protein quantification, protein-protein, protein-lipid, or protein-ATP interactions, in silico lead identification, protein arrays, tissue and cell extract preparation, labeling, chemoproteomics, and drug efficacy assessment. Emphasis was placed not just on methods that describe large-scale protein analysis, but also on ones that are amenable to future implementation in a high-throughput format. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Proteomics for Drug Discovery: Methods and Protocols aims to provide a deep knowledge of the fundamentals of disease biology as well the means that were developed for probing the complex biological milieu. 316 pp. Englisch. N� de r�f. du vendeur 9781493972005

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Proteomics for Drug Discovery : Methods and Protocols

Edit� par Humana Press, 2017

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Proteomics for Drug Discovery : Methods and Protocols

Iulia M. Lazar

Edit� par Springer New York, Springer US, 2017

ISBN 10 : 1493972006 ISBN 13 : 9781493972005

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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This book reflects the drug development community's interest in proteomics methods by providing researchers with the necessary knowledge for the implementation of a number of basic experimental and bioinformatics protocols in the drug discovery research laboratory. The focus of the collection is on select protocols and methodologies that address the analysis of post-translational modifications, targeted protein quantification, protein-protein, protein-lipid, or protein-ATP interactions, in silico lead identification, protein arrays, tissue and cell extract preparation, labeling, chemoproteomics, and drug efficacy assessment. Emphasis was placed not just on methods that describe large-scale protein analysis, but also on ones that are amenable to future implementation in a high-throughput format. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Proteomics for Drug Discovery: Methods and Protocols aims to provide a deep knowledge of the fundamentals of disease biology as well the means that were developed for probing the complex biological milieu. N� de r�f. du vendeur 9781493972005

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Proteomics for Drug Discovery

Iulia M. Lazar

Edit� par Springer New York, Springer US Aug 2017, 2017

ISBN 10 : 1493972006 ISBN 13 : 9781493972005

Neuf Couverture rigide

Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

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Buch. Etat : Neu. Neuware -This book reflects the drug development community�s interest in proteomics methods by providing researchers with the necessary knowledge for the implementation of a number of basic experimental and bioinformatics protocols in the drug discovery research laboratory. The focus of the collection is on select protocols and methodologies that address the analysis of post-translational modifications, targeted protein quantification, protein-protein, protein-lipid, or protein-ATP interactions, in silicolead identification, protein arrays, tissue and cell extract preparation, labeling, chemoproteomics, and drug efficacy assessment. Emphasis was placed not just on methods that describe large-scale protein analysis, but also on ones that are amenable to future implementation in a high-throughput format. Written in the highly successfulMethods in Molecular Biologyseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 316 pp. Englisch. N� de r�f. du vendeur 9781493972005

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