Part I: Introduction to Teratology Testing
1. An Overview of Teratology
Ana M. Calado and Maria dos Anjos Pires
2. Teratology Study Guidelines: An Overview
Sofia Alves-Pimenta, Luís Félix, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio
3. Biological Concerns on the Selection of Animal Models for Teratogenic Testing
Sofia Alves-Pimenta, Bruno Colaço, Paula A. Oliveira, and Carlos Venâncio
Part II: In Vitro-Based Teratology Screening
4. The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
Lauren M. Walker, Darcie L.V. McClelland-Descalzo, and Nicole I. zur Nieden
5. Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage
Joseph V. Madrid, Steven R. Sera, Nicole R.L. Sparks, and Nicole I. zur Nieden
6. Chick Embryonic Cardiomyocytes Micromass System for Assessing Developmental Cardiotoxicity of Drugs
Wasay M.S. Qureshi and Margaret K. Pratten
7. Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell
Valéria Maria Lara, Kelly C. Santos Roballo, André Tadeu Gotardo, and Carlos Eduardo Ambrósio
8. Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs
Bo Liang and Chi C. Wang
9. Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents
Carlos Martins-Gomes and Amélia M. Silva
10. Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology
Fuqiang Yuan and Shao-yu Chen
Part III: Animal-Based Teratology Methods
11. Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
Caralina M. de Evsikova
12. Effect of Teratogens on Development of Drosophila melanogaster
Dong Li and Xiaolin Bi
13. Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
Matheus C. Bianchini, José L.R. Portela, Robson L. Puntel, and Daiana S. Ávila
14. Behavioral Teratogenesis in Drosophila melanogaster
Monalisa Mishra and Bedanta Kumar Barik
15. Evaluation of the Teratogenicity of Pharmaceuticals Using FETAX
Hariz Islas-Flores, Itzayana Pérez-Alvaréz, and Leobardo M. Gómez-Oliván
16. Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays
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Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
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Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Includes cutting-edge methods and protocols for the study of teratogenicity testing and assessmentProvides step-by-step detail essential for reproducible resultsContains key notes and implementation advice from . N° de réf. du vendeur 447957532
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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs. 632 pp. Englisch. N° de réf. du vendeur 9781493978823
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Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 632 pp. Englisch. N° de réf. du vendeur 9781493978823
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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This detailed book provides a compilation of laboratory techniques and tests to assess the risks to embryo-fetal development from drug exposure during early developmental stages. After an introduction to teratogenicity testing, the contents explore both in vitro and in vivo techniques in the study of the teratogenic and fetotoxic effects of drugs, as well as numerous animal-based teratology methods. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Teratogenicity Testing: Methods and Protocols describes methods that integrate a battery of tests that can be performed in cells, organs, tissues, and animal models for evaluating toxicity and/or the safety of compounds in early developmental stages with the goal of estimating, preventing, or minimizing the teratogenic potential of drugs. N° de réf. du vendeur 9781493978823
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