Water-Insoluble Drug Formulation - Couverture rigide

Couverture rigide

ISBN 10 : 149872941X ISBN 13 : 9781498729413

Editeur : CRC Press Inc, 2018

Synopsis

Properties and Formulation: From Theory to Real-World Application

Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development.

In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field.

The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

A propos du livre

À propos de l'auteur

Ron Liu is CEO of AustarPharma, a pharmaceutical company based in Edison, New Jersey.

À propos de la quatrième de couverture

Water-Insoluble Drug Formulation, Third Edition serves as a comprehensive reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs.

Détails de l'édition

• Éditeur: CRC Press Inc
• Date d'édition: 2018
• Langue: anglais
• ISBN 10: 149872941X
• ISBN 13: 9781498729413
• Reliure: Relié
• Numéro d'édition: 3
• Nombre de pages: 736
• Éditeur: Liu Ron
• Coordonnées du fabricant: non disponible
• Personne responsable: gpsr@libri.de; gpsr@libri.de; ; Europaallee 1; Bad Hersfeld; 36244; Allemagne