Stochastic Modelling for Systems Biology - Couverture rigide

Wilkinson, Darren J.

 
9781584885405: Stochastic Modelling for Systems Biology
Couverture rigide
ISBN 10 : 1584885408 ISBN 13 : 9781584885405
Editeur : CRC Press Inc, 2006

Synopsis

Although stochastic kinetic models are increasingly accepted as the best way to represent and simulate genetic and biochemical networks, most researchers in the field have limited knowledge of stochastic process theory. The stochastic processes formalism provides a beautiful, elegant, and coherent foundation for chemical kinetics and there is a wealth of associated theory every bit as powerful and elegant as that for conventional continuous deterministic models. The time is right for an introductory text written from this perspective.

Stochastic Modelling for Systems Biology presents an accessible introduction to stochastic modelling using examples that are familiar to systems biology researchers. Focusing on computer simulation, the author examines the use of stochastic processes for modelling biological systems. He provides a comprehensive understanding of stochastic kinetic modelling of biological networks in the systems biology context. The text covers the latest simulation techniques and research material, such as parameter inference, and includes many examples and figures as well as software code in R for various applications.

While emphasizing the necessary probabilistic and stochastic methods, the author takes a practical approach, rooting his theoretical development in discussions of the intended application. Written with self-study in mind, the book includes technical chapters that deal with the difficult problems of inference for stochastic kinetic models from experimental data. Providing enough background information to make the subject accessible to the non-specialist, the book integrates a fairly diverse literature into a single convenient and notationally consistent source.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Although stochastic kinetic models are increasingly accepted as the best way to represent and simulate genetic and biochemical networks, most researchers in the field have limited knowledge of stochastic process theory. The stochastic processes formalism provides a beautiful, elegant, and coherent foundation for chemical kinetics and there is a wealth of associated theory every bit as powerful and elegant as that for conventional continuous deterministic models. The time is right for an introductory text written from this perspective.

Stochastic Modelling for Systems Biology presents an accessible introduction to stochastic modelling using examples that are familiar to systems biology researchers. Focusing on computer simulation, the author examines the use of stochastic processes for modelling biological systems. He provides a comprehensive understanding of stochastic kinetic modelling of biological networks in the systems biology context. The text covers the latest simulation techniques and research material, such as parameter inference, and includes many examples and figures as well as software code in R for various applications.

While emphasizing the necessary probabilistic and stochastic methods, the author takes a practical approach, rooting his theoretical development in discussions of the intended application. Written with self-study in mind, the book includes technical chapters that deal with the difficult problems of inference for stochastic kinetic models from experimental data. Providing enough background information to make the subject accessible to the non-specialist, the book integrates a fairly diverse literature into a single convenient and notationally consistent source.

Biographie de l'auteur

Darren Wilkinson is Professor of Stochastic Modelling at Newcastle University in the UK. He was educated at the nearby University of Durham, where he took his first degree in Mathematics, followed by a Ph.D. in Bayesian statistics which he completed in 1995. He moved to a lectureship in statistics at the Newcastle University in 1996, where he has remained since, being promoted to his current post in 2007. Professor Wilkinson is interested in computational statistics and Bayesian inference and in the application of modern statistical technology to problems in statistical bioinformatics and systems biology. He is involved in a variety of systems biology projects at Newcastle, including the Centre for Integrated Systems Biology of Ageing and Nutrition (CISBAN). He recently held a BBSRC Research Development Fellowship on Integrative modelling of stochasticity, noise, heterogeneity and measurement error in the study of model biological systems.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
CRC Press Inc
Date d'édition
2006
Langue
anglais
ISBN 10 
1584885408
ISBN 13 
9781584885405
Reliure
Relié
Nombre de pages
280
Coordonnées du fabricant
non disponible
Personne responsable
non disponible

Autres éditions populaires du même titre

9781439837726: Stochastic Modelling for Systems Biology

Edition présentée

ISBN 10 :  1439837724 ISBN 13 :  9781439837726
Editeur : CRC Press Inc, 2011
Couverture rigide