Cancer Cell Signaling: Methods and Protocols - Couverture rigide

Couverture rigide

ISBN 10 : 1588290751 ISBN 13 : 9781588290755

Editeur : Humana Press Inc., 2002

Synopsis

Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transd- tion that directly contribute to a loss of this division-limited equilibrium and the progression to malignant transformation. The study of cell-signaling m- ecules in this context is a central component of cancer research. From the knowledge of such targets, investigators have been able to productively advance many insightful hypotheses about how a particular cancer cell may misinterpret, or respond inappropriately to, growth regulatory cues in their environment. Despite these key insights, the rapidly evolving nature of cell signaling research in cancer has necessitated a continuous revision of these theoretical constructs and the updating of methods used in their study. One contemporary example of the evolution of this field is provided by an analysis of the Human Genome Project data, which reveal a previously unsuspected diversity in the multigene families encoding for most signaling pathway int- mediates. In assessing the usefulness of a particular methodological approach, therefore, we will need to keep in mind that there is a premium on those p- tocols that can be easily adapted for the analysis of multiple members within a gene family. Cancer Cell Signaling: Methods and Protocols brings together several such methods in cell signaling research that are scientifically grounded within the cancer biology field.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 2002
• Langue: anglais
• ISBN 10: 1588290751
• ISBN 13: 9781588290755
• Reliure: Relié
• Nombre de pages: 348
• Éditeur: Terrian David M.
• Coordonnées du fabricant: non disponible
• Personne responsable: HUMANA SPAIN S.L.; https://www.humana-spain.org/?lang=en; ; Av Alberto Alcocer 46, 5-B; Madrid; 28016; Espagne