G Protein Signaling: Methods and Protocols - Couverture rigide

Couverture rigide

ISBN 10 : 1588291375 ISBN 13 : 9781588291370

Editeur : Humana Press Inc., 2003

Synopsis

Since the initial discovery of the G protein-coupled receptor system that regulates cyclicAMP production, the G protein field has rapidly expanded. Cell surface receptors that couple to heterotrimeric G proteins, the G prote- coupled receptors (GPCRs), number in the hundreds and bind to a wide div- sity of ligands including, biogenic amines (e. g., adrenaline), lipid derivatives (e. g., lysophosphatidic acid), peptides (e. g., opioid peptides), proteins (e. g., thyroid-stimulating hormone), and odorants to name a few. The GPCR system is found throughout biology in such simple organisms as yeast and in such more complex organisms as Dictyostelium discoideum (slime mold), Caen- habditis elegans (nematode worm), and of course in humans. GPCRs and their associated G protein systems are the subject of intense academic research and because of their involvement in a human biology and disease, the pharmac- tical industry has large research initiatives dedicated to the study of GPCRs. By some estimates, more than 50% of the pharmaceuticals on the market are targeted at GPCRs. The G protein/G protein-coupled receptor system consists of a receptor (GPCR), a heterotrimeric G protein consisting of ?, ?, and ? subunits, and an effector. G protein effector molecules, such as enzymes or ion channels, respond to acti- tion by the G protein to generate second messengers or changes in membrane potential that lead to alterations in cell physiology.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 2003
• Langue: anglais
• ISBN 10: 1588291375
• ISBN 13: 9781588291370
• Reliure: Relié
• Nombre de pages: 262
• Éditeur: Smrcka Alan V.
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible