Molecular Neurosurgery with Targeted Toxins - Couverture rigide

Couverture rigide

ISBN 10 : 1588291995 ISBN 13 : 9781588291998

Editeur : Humana Press Inc., 2005

Synopsis

Pioneers and leading researchers explain the theory and techniques of using targeted toxins experimentally. The highly successful use of the 192 IgG-saporin and ME20.4-saporin immunotoxins to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals is treated in detail too give a potential user the knowledge to comfortably use the techniques involved. The uses of important new lesioning agents such as anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of CNS demyelination are explained by experts in the field.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 2005
• Langue: anglais
• ISBN 10: 1588291995
• ISBN 13: 9781588291998
• Reliure: Relié
• Nombre de pages: 324
• Éditeur: Wiley Ronald G., Lappi Douglas A.
• Coordonnées du fabricant: Springer Nature Customer Service Center GmbH; ProductSafety@springernature.com; ; Europaplatz 3; Heidelberg; 69115; Allemagne