Transforming Growth Factor-beta in Cancer Therapy (2) - Couverture rigide

Couverture rigide

ISBN 10 : 1588297152 ISBN 13 : 9781588297150

Editeur : Humana Press Inc., 2008

Synopsis

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 2008
• Langue: anglais
• ISBN 10: 1588297152
• ISBN 13: 9781588297150
• Reliure: Relié
• Nombre de pages: 812
• Éditeur: Jakowlew Sonia B.
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne