G-Quadruplex DNA: Methods and Protocols - Couverture rigide

Couverture rigide

ISBN 10 : 1588299503 ISBN 13 : 9781588299505

Editeur : Humana Press Inc., 2009

Synopsis

Recent work has revealed that stabilizing G-quadruplexes in telomeric DNA inhibits telomerase activity, providing impetus for the development of G-quartet-interacting drugs, while G-quartet-containing oligonucleotides have been recognized as a potent class of aptamers effective against STAT3 and other transcription factors implicated in oncogenesis, proving these guanine-quartets to be a vital and rich area for future study. In "G-Quadruplex DNA: Methods and Protocols", experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. Written in the highly successful Methods in Molecular Biology(TM) series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, "G-Quadruplex DNA: Methods and Protocols "promises to be a useful resource for those familiar with G-quartets as well as an easy entry point for those researchers from diverse fields who are just developing an interest in the exciting implications of G-quadruplex DNA.

A propos du livre

Présentation de l'éditeur

In this authoritative book, experts in the field present a collection of detailed techniques for studying G-quartet formation, dynamics, and molecular recognition. It provides detailed protocols which ensure successful re-recreation of experimental procedures.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 2009
• Langue: anglais
• ISBN 10: 1588299503
• ISBN 13: 9781588299505
• Reliure: Relié
• Nombre de pages: 288
• Éditeur: Baumann Peter
• Coordonnées du fabricant: GPSR Kontakt; ProductSafety@springernature.com; ; Abraham-Lincoln-Str. 46; Wiesbaden; 65189; Allemagne