Measles Virus Nucleoprotein - Couverture rigide

Couverture rigide

ISBN 10 : 1600216293 ISBN 13 : 9781600216299

Editeur : Nova Science Publishers Inc, 2007

Synopsis

Measles virus possesses a non segmented, single stranded, negative sense RNA genome that is encapsidated by the nucleoprotein to form a helical nucleocapsid. This ribonucleoproteic complex is the substrate for both transcription and replication. The RNAdependent RNA polymerase binds to the nucleocapsid template via its co-factor, the phosphoprotein. This book focuses on the main structural information available on the nucleoprotein, showing that it consists of a structured core (NCORE) and of an intrinsically disordered C-terminal domain (NTAIL). The functional implications of the disordered nature of NTAIL are discussed in light of the ability of disordered regions to establish interactions with multiple partners, thus leading to multiple biological effects. Indeed, beyond the phosphoprotein, NTAIL also interacts with cellular partners, including the major heat shock protein, hsp72, the interferon regulator factor 3, IRF3, and a yet unidentified cellular receptor referred to as NR. This book consists of two chapters devoted to the general functions of the nucleoprotein in transcription and replication and to a detailed overview of its structural properties, and of three chapters focused on the functional relevance of the interaction between NTAIL and its various intracellular and extracellular partners.

Détails de l'édition

• Éditeur: Nova Science Publishers Inc
• Date d'édition: 2007
• Langue: anglais
• ISBN 10: 1600216293
• ISBN 13: 9781600216299
• Reliure: Relié
• Numéro d'édition: 1
• Nombre de pages: 163
• Éditeur: Longhi Sonia
• Coordonnées du fabricant: non disponible
• Personne responsable: eucomply OÜ; hello@eucompliancepartner.com; ; Pärnu mnt 139b-14; Tallinn; 11317; Estonie