Mannose-Binding Lectin in the Innate Immune System - Couverture souple

Messias-Reason, Iara De; Boldt, Angelica B W

Couverture souple

ISBN 10 : 1606927167 ISBN 13 : 9781606927168

Editeur : Nova Science Publishers Inc, 2009

Synopsis

Mannose-binding lectin (MBL) is a plasma protein with an important role in the innate immune system. MBL recognises pathogens through carbohydrate structures present on the surface of a range of pathogenic organisms including viruses, bacteria, fungi and protozoans. These structures may be referred to as pathogen-associated molecular patterns (PAMPs). After binding to PAMPs, MBL promotes C1- and antibody-independent activation of complement, leading to complement-mediated killing and/or phagocytosis. MBL is also known to modulate the secretion of cytokines from macrophages and to mediate the clearance of apoptotic cells as such playing a role in the inflammatory response. This book summarises the actual understanding of human MBL biology and introduces the general aspects of the structure, function and genetics of MBL, as well as an analysis of the role of MBL in the predisposition to clinically relevant diseases.

Détails de l'édition

• Éditeur: Nova Science Publishers Inc
• Date d'édition: 2009
• Langue: anglais
• ISBN 10: 1606927167
• ISBN 13: 9781606927168
• Reliure: Broché
• Nombre de pages: 90
• Coordonnées du fabricant: non disponible
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