Molecular Mechanisms Involved in the Pathogenesis of Huntington's Disease - Couverture souple

Perandones, Claudia; Micheli, Federico Eduardo; Radrizzani, Martín

 
9781617289712: Molecular Mechanisms Involved in the Pathogenesis of Huntington's Disease
Couverture souple
ISBN 10 : 161728971X ISBN 13 : 9781617289712
Editeur : Nova Science Publishers Inc, 2011

Synopsis

Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disorder with a distinct phenotype, including chorea, incoordination, cognitive decline, and behavioural difficulties. The underlying genetic defect responsible for the disease is the expansion of a CAG repeat in the gene coding for the HD protein, huntingtin (htt). This CAG repeat is an unstable triplet repeat DNA sequence, and its length is inversely correlated with the age at onset of the disease. Expanded CAG repeats have been found in 8 other inherited neurodegenerative diseases. Despite its widespread distribution, mutant htt causes selective neurodegeneration, which occurs preferentially and most prominently in the striatum and deeper layers of the cortex. This book focuses on HD, outlining the effects of mutant htt in the nucleus and cytoplasm as well as the role of cell-cell interactions in the HD pathology.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
Nova Science Publishers Inc
Date d'édition
2011
Langue
anglais
ISBN 10 
161728971X
ISBN 13 
9781617289712
Reliure
Broché
Numéro d'édition
1
Nombre de pages
56
Coordonnées du fabricant
non disponible
Personne responsable
non disponible