Articles liés à Chiral Separations: Methods and Protocols

Chiral Separations: Methods and Protocols ISBN 13 : 9781617373909

Chiral Separations: Methods and Protocols - Couverture souple

 
9781617373909: Chiral Separations: Methods and Protocols

Synopsis

Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to be chiral and only about 25% are administered as pure enantiomers. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). In several cases, unwanted side effects or even toxic effects may occur with the inactive enantiomer (distomer). Even if the side effects are not that drastic, the inactive enantiomer has to be meta- lized, which represents an unnecessary burden for the organism. The admin- tration of pure, pharmacologically active enantiomers is therefore of great importance. The ideal way to get to pure enantiomers would be by enantioselective synthesis. However, this approach is usually expensive and not often practicable. Usually, the racemates are obtained in a synthesis, and the separation of the enantiomers on a preparative scale is necessary.On the other hand, there is also a great demand for methods of enantiomer separation on an analytical scale for controlling synthesis, checking for racemization p- cesses, controlling enantiomeric purity, and for pharmacokinetic studies. C- ventional methods for enantiomer separation on a preparative scale are fractionated crystallization, the formation of diastereomeric pairs followed by repeated recrystallization, and enzymatic procedures. In recent years, ch- matographic methods such as gas chromatography and, especially, liquid ch- matography have attracted increasing interest for chiral separation, both on analytical and preparative scales.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

  • ÉditeurHumana
  • Date d'édition2010
  • ISBN 10 1617373907
  • ISBN 13 9781617373909
  • ReliureBroché
  • Langueanglais
  • Numéro d'édition1
  • Nombre de pages448
  • ÉditeurGübitz Gerald, Schmid Martin G.
  • Coordonnées du fabricantnon disponible

Acheter D'occasion

état :  Comme neuf
Like New
Afficher cet article
EUR 167,39

Autre devise

EUR 29,66 expédition depuis Royaume-Uni vers France

Destinations, frais et délais

Acheter neuf

Afficher cet article
EUR 92,27

Autre devise

EUR 9,70 expédition depuis Allemagne vers France

Destinations, frais et délais

Autres éditions populaires du même titre

9781588291509: Chiral Separations: Methods and Protocols

Edition présentée

ISBN 10 :  1588291502 ISBN 13 :  9781588291509
Editeur : Humana Press Inc., 2003
Couverture rigide

Résultats de recherche pour Chiral Separations: Methods and Protocols

Image fournie par le vendeur

Gübitz, Gerald|Schmid, Martin G.
Edité par Humana Press, 2010
ISBN 10 : 1617373907 ISBN 13 : 9781617373909
Neuf Couverture souple
impression à la demande

Vendeur : moluna, Greven, Allemagne

Évaluation du vendeur 5 sur 5 étoiles Evaluation 5 étoiles, En savoir plus sur les évaluations des vendeurs

Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Includes supplementary material: sn.pub/extrasChiral Separation Principles: An Introduction Gerald Guebitz and Martin G. Schmid Separation of Enantiomers by Thin-Layer Chromatography: An Overview Kurt Guenther, Peter Richter, and Klaus Moeller Cyc. N° de réf. du vendeur 4256810

Contacter le vendeur

Acheter neuf

EUR 92,27
Autre devise
Frais de port : EUR 9,70
De Allemagne vers France
Destinations, frais et délais

Quantité disponible : Plus de 20 disponibles

Ajouter au panier

Image fournie par le vendeur

Martin G. Schmid
Edité par Humana Press Dez 2010, 2010
ISBN 10 : 1617373907 ISBN 13 : 9781617373909
Neuf Taschenbuch
impression à la demande

Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne

Évaluation du vendeur 5 sur 5 étoiles Evaluation 5 étoiles, En savoir plus sur les évaluations des vendeurs

Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Methods for enantiomer separation are very important for controlling synthesis, for checking racemization, for enantiomeric purity control, and for pharmacokinetic studies. In Chiral Separations: Methods and Protocols, prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotogrphic, gas chromatographic, and supercritical fluid chromatographic as well as recent electrochromotographic techniques. Each fully tested protocol includes an introduction to the principle underlying the method, equipment and reagent lists, and helpful notes on troubleshooting and avoiding known pitfalls. Up-to-date and highly practical, Chiral Separations: Methods and Protocols will help both novice and advanced users not only choose optimal methods for their separation problems, but also readily obtain successful results. 448 pp. Englisch. N° de réf. du vendeur 9781617373909

Contacter le vendeur

Acheter neuf

EUR 106,99
Autre devise
Frais de port : EUR 11
De Allemagne vers France
Destinations, frais et délais

Quantité disponible : 2 disponible(s)

Ajouter au panier

Image fournie par le vendeur

Martin G. Schmid
ISBN 10 : 1617373907 ISBN 13 : 9781617373909
Neuf Taschenbuch
impression à la demande

Vendeur : buchversandmimpf2000, Emtmannsberg, BAYE, Allemagne

Évaluation du vendeur 5 sur 5 étoiles Evaluation 5 étoiles, En savoir plus sur les évaluations des vendeurs

Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Many compounds of biological and pharmacological interest are as- metric and show optical activity. Approximately 40% of the drugs in use are known to be chiral and only about 25% are administered as pure enantiomers. It is well established that the pharmacological activity is mostly restricted to one of the enantiomers (eutomer). In several cases, unwanted side effects or even toxic effects may occur with the inactive enantiomer (distomer). Even if the side effects are not that drastic, the inactive enantiomer has to be meta- lized, which represents an unnecessary burden for the organism. The admin- tration of pure, pharmacologically active enantiomers is therefore of great importance. The ideal way to get to pure enantiomers would be by enantioselective synthesis. However, this approach is usually expensive and not often practicable. Usually, the racemates are obtained in a synthesis, and the separation of the enantiomers on a preparative scale is necessary. On the other hand, there is also a great demand for methods of enantiomer separation on an analytical scale for controlling synthesis, checking for racemization p- cesses, controlling enantiomeric purity, and for pharmacokinetic studies. C- ventional methods for enantiomer separation on a preparative scale are fractionated crystallization, the formation of diastereomeric pairs followed by repeated recrystallization, and enzymatic procedures. In recent years, ch- matographic methods such as gas chromatography and, especially, liquid ch- matography have attracted increasing interest for chiral separation, both on analytical and preparative scales. 448 pp. Englisch. N° de réf. du vendeur 9781617373909

Contacter le vendeur

Acheter neuf

EUR 106,99
Autre devise
Frais de port : EUR 15
De Allemagne vers France
Destinations, frais et délais

Quantité disponible : 1 disponible(s)

Ajouter au panier

Image fournie par le vendeur

Martin G. Schmid
Edité par Humana Press, Humana Press, 2010
ISBN 10 : 1617373907 ISBN 13 : 9781617373909
Neuf Taschenbuch
impression à la demande

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

Évaluation du vendeur 5 sur 5 étoiles Evaluation 5 étoiles, En savoir plus sur les évaluations des vendeurs

Taschenbuch. Etat : Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Methods for enantiomer separation are very important for controlling synthesis, for checking racemization, for enantiomeric purity control, and for pharmacokinetic studies. In Chiral Separations: Methods and Protocols, prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotogrphic, gas chromatographic, and supercritical fluid chromatographic as well as recent electrochromotographic techniques. Each fully tested protocol includes an introduction to the principle underlying the method, equipment and reagent lists, and helpful notes on troubleshooting and avoiding known pitfalls. Up-to-date and highly practical, Chiral Separations: Methods and Protocols will help both novice and advanced users not only choose optimal methods for their separation problems, but also readily obtain successful results. N° de réf. du vendeur 9781617373909

Contacter le vendeur

Acheter neuf

EUR 111,53
Autre devise
Frais de port : EUR 10,99
De Allemagne vers France
Destinations, frais et délais

Quantité disponible : 1 disponible(s)

Ajouter au panier

Image d'archives

Gübitz, Gerald (Editor) / Schmid, Martin G. (Editor)
Edité par Humana Press, 2010
ISBN 10 : 1617373907 ISBN 13 : 9781617373909
Neuf Paperback

Vendeur : Revaluation Books, Exeter, Royaume-Uni

Évaluation du vendeur 5 sur 5 étoiles Evaluation 5 étoiles, En savoir plus sur les évaluations des vendeurs

Paperback. Etat : Brand New. reprint edition. 448 pages. 9.25x6.10x1.01 inches. In Stock. N° de réf. du vendeur zk1617373907

Contacter le vendeur

Acheter neuf

EUR 182,10
Autre devise
Frais de port : EUR 11,86
De Royaume-Uni vers France
Destinations, frais et délais

Quantité disponible : 1 disponible(s)

Ajouter au panier

Image d'archives

Edité par Humana, 2010
ISBN 10 : 1617373907 ISBN 13 : 9781617373909
Ancien ou d'occasion Paperback

Vendeur : Mispah books, Redhill, SURRE, Royaume-Uni

Évaluation du vendeur 4 sur 5 étoiles Evaluation 4 étoiles, En savoir plus sur les évaluations des vendeurs

Paperback. Etat : Like New. Like New. book. N° de réf. du vendeur ERICA79016173739076

Contacter le vendeur

Acheter D'occasion

EUR 167,39
Autre devise
Frais de port : EUR 29,66
De Royaume-Uni vers France
Destinations, frais et délais

Quantité disponible : 1 disponible(s)

Ajouter au panier