Prion Biology: A Subject Collection from Cold Spring Perspectives in Biology - Couverture rigide

Couverture rigide

ISBN 10 : 1621820939 ISBN 13 : 9781621820932

Editeur : Cold Spring Harbor Laboratory Press,U.S., 2017

Synopsis

Prions are best known as the agents of mad cow and related diseases, and a growing number of proteins with prion-like properties have been implicated in diseases such as Parkinson's. But some recently discovered prion-like proteins do not appear to induce pathological changes and, in fact, may be key players in basic biological processes such as transcription, immune regulation, and memory formation.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the expanding roles of prions and prion-like proteins in health and disease. The contributors review the structures of prions and prion-like proteins, how they aggregate into amyloid fibrils and other insoluble complexes, and the unique biological properties of the aggregated forms (e.g., infectivity, gain/loss of function, and self-templating). The normal physiological roles of prion-like proteins (e.g., CPEB in the brain and MAVS in the immune response) are discussed, as is the formation of abnormal protein aggregates via prion-like mechanisms in various human diseases.

The authors also discuss prions in yeast and other fungi, which are convenient models for studying mechanisms of amyloid formation and propagation. This volume is therefore an essential reference for biochemists, cell and molecular biologists, and all who wish to understand how these alternatively folded, self-propagating proteins function.

Détails de l'édition

• Éditeur: Cold Spring Harbor Laboratory Press,U.S.
• Date d'édition: 2017
• Langue: anglais
• ISBN 10: 1621820939
• ISBN 13: 9781621820932
• Reliure: Relié
• Nombre de pages: 456
• Éditeur: Prusiner Stanley B
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible