Optimization in Drug Discovery: In Vitro Methods - Couverture rigide

Couverture rigide

ISBN 10 : 1627037411 ISBN 13 : 9781627037419

Editeur : Humana Press Inc., 2013

Synopsis

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates.

Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

Détails de l'édition

• Éditeur: Humana Press Inc.
• Date d'édition: 2013
• Langue: anglais
• ISBN 10: 1627037411
• ISBN 13: 9781627037419
• Reliure: Relié
• Numéro d'édition: 2
• Nombre de pages: 614
• Éditeur: Caldwell Gary W., Yan Zhengyin
• Coordonnées du fabricant: Buchpark GmbH; https://www.buchpark.de; ; Krügerweg 1; Trebbin; Brandenburg; 14959; Allemagne