Intrinsically Disordered Proteins: Structural Characterization, Therapeutic Applications and Future Directions - Couverture rigide

Couverture rigide

ISBN 10 : 1634844076 ISBN 13 : 9781634844079

Editeur : Nova Science Publishers Inc, 2016

Synopsis

Intrinsically disordered proteins (IDPs) are biomolecules that do not have a definite 3D structure; their role in the biochemical network of a cell relates to their ability to switch rapidly among different secondary and tertiary structures. The emergence of IDPs has challenged the classical protein structure-function paradigm. IDPs play an important role in cellular regulation, signaling and control in health and disease. However, the unusual biophysics of these proteins makes structural characterisation of IDPs and their complexes not only challenging but often resulting in opposite conclusions. This book studies the structural characterisation and future directions of IDPs. Chapter One focuses on the DNA-binding IDPs and how intrinsic disorder affects their function. Chapter Two discusses the use of a computer atomistic simulation for the structural analysis of IDPs. The final chapter, Chapter Three, examines two long-standing contradictions concerning dimerisation and membrane-binding activities of IDPs; provides an explanation of these discrepancies; and demonstrates how the resolution of these critical issues in the field results in the expanded understanding of cell function with multiple applications in biology and medicine.

Détails de l'édition

• Éditeur: Nova Science Publishers Inc
• Date d'édition: 2016
• Langue: anglais
• ISBN 10: 1634844076
• ISBN 13: 9781634844079
• Reliure: Relié
• Nombre de pages: 120
• Éditeur: Weber Violet
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible