Dissecting the Role of Mitochondria in the Pathophysiology of Type-2 Diabetes and Obesity: Novel Concepts and Challenges - Couverture souple

Claret, Marc

Couverture souple

ISBN 10 : 1681086786 ISBN 13 : 9781681086781

Editeur : Bentham Science Publishers, 2017

Synopsis

Extensive evidence from animal and clinical studies indicates an intimate connection between mitochondrial dysfunction and metabolic pathologies such as obesity and type-2 diabetes. In recent years, the traditional view of the mitochondria as being just the powerhouse of the cell has greatly evolved. It is currently appreciated that this organelle is critical for a wide-range of biological functions and that it also plays a fundamental role as a signaling platform. Given the biological relevance of these less-studied mitochondrial functions and the bulk of information accumulated on this matter during the last decade, it is not surprising the renewed and growing interest on this organelle and the exploration of potential links with metabolic conditions. Thus, the goal of this thematic issue of Current Diabetes Reviews is to provide a comprehensive update on novel concepts in mitochondrial biology in the context of obesity and type-2 diabetes. This volume presents the following reviews: • Mitochondrial post-translational Modifications and Metabolic Control: Sirtuins and Beyond • Autophagy and Mitochondria in Obesity and Type 2 Diabetes • Emerging Concepts in Diabetes: Mitochondrial Dynamics and Glucose Homeostasis • Mitochondrial Uncoupling and the Regulation of Glucose Homeostasis • Targeting Mitochondrial Biogenesis and Mitochondrial Substrate Utilization to Treat Obesity and Insulin Resistance, Respectively – Two Data-Driven Hypotheses This issue is essential reading for readers involved in research on the endocrinology and molecular biology of diabetes and obesity. Physiologists and medical residents can also benefit from the information presented in the reviews.

Détails de l'édition

• Éditeur: Bentham Science Publishers
• Date d'édition: 2017
• Langue: anglais
• ISBN 10: 1681086786
• ISBN 13: 9781681086781
• Reliure: Broché
• Nombre de pages: 105
• Éditeur: Garcia-Roves Pablo M
• Coordonnées du fabricant: Manufactured by Amazon on behalf of the author; https://www.amazon.fr/hz/contact-us; ; c/o Amazon Media EU S.à.r.l., 38 Avenue John F. Kennedy; Luxembourg; L-1855; Luxembourg