Computational Approaches for Drug Solubility Measurements - Couverture souple

Singh, Dilpreet

Couverture souple

ISBN 10 : 1685387225 ISBN 13 : 9781685387228

Editeur : Notion Press, 2021

Synopsis

olubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. More than 40% NCEs (new chemical entities) developed in pharmaceutical industry are practically insoluble in water. Solubility is a major challenge for formulation scientist. Any drug to be absorbed must be present in the form of solution at the site of absorption. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.

Détails de l'édition

• Éditeur: Notion Press
• Date d'édition: 2021
• Langue: anglais
• ISBN 10: 1685387225
• ISBN 13: 9781685387228
• Reliure: Broché
• Nombre de pages: 98
• Coordonnées du fabricant: non disponible
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