Ubiquitin: Proteasome Pathway - Couverture rigide

Couverture rigide

ISBN 10 : 1838804323 ISBN 13 : 9781838804329

Editeur : IntechOpen, 2020

Synopsis

The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.

Détails de l'édition

• Éditeur: IntechOpen
• Date d'édition: 2020
• Langue: anglais
• ISBN 10: 1838804323
• ISBN 13: 9781838804329
• Reliure: Relié
• Nombre de pages: 124
• Éditeur: Zhan Xianquan
• Coordonnées du fabricant: IN TECH d.o.o.; info@intechopen.com; ; Prolaz Marije Krucifikse Kozuli¿ 3; Rijeka; 51000; Croatie