Matrix Metalloproteinases in the Central Nervous System - Couverture rigide

Conant, Katherine; Gottschall, Paul E

Couverture rigide

ISBN 10 : 1860945597 ISBN 13 : 9781860945595

Editeur : Imperial College Press, 2005

Synopsis

This book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue destruction, which is observed with inflammatory and degenerative conditions of the brain. The book provides a background on the biology of MMPs, and on the stimuli and conditions that are linked to an increase in their production and activity. It describes the targets of MMPs, which include matrix proteins such as collagen, soluble cytokines and chemokines, and cell surface receptors. Studies implicating MMPs in neuronal process outgrowth and cell migration in CNS development are covered. The book also touches on studies suggesting that, in certain situations, dysregulated MMP activity and/or production may be critical to blood-brain barrier breakdown and neuronal damage.

Détails de l'édition

• Éditeur: Imperial College Press
• Date d'édition: 2005
• Langue: anglais
• ISBN 10: 1860945597
• ISBN 13: 9781860945595
• Reliure: Relié
• Nombre de pages: 348
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible