Articles liés à The Biology of Alzheimer Disease

The Biology of Alzheimer Disease - Couverture souple

 
9781936113446: The Biology of Alzheimer Disease
Couverture souple
ISBN 10 : 1936113449 ISBN 13 : 9781936113446
Editeur : Cold Spring Harbor Laboratory Press,U.S., 2011

Synopsis

Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progresses-including the accumulation of amyloid plaques and neurofibrillary tangles-is critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this volume from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid ?-protein precursor (APP), tau, presenilin, ?-secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the brain as the disease progresses-including the accumulation of amyloid plaques and neurofibrillary tangles-is critical for the development of successful therapeutic approaches. Written and edited by leading experts in the field, this volume from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of Alzheimer disease, from our current molecular understanding to therapeutic agents that could be used to treat and, ultimately, prevent it. Contributors discuss the biochemistry and cell biology of amyloid ?-protein precursor (APP), tau, presenilin, ?-secretase, and apolipoprotein E and their involvement in Alzheimer disease. They also review the clinical, neuropathological, imaging, and biomarker phenotypes of the disease; genetic alterations associated with the disorder; and epidemiological insights into its causation and pathogenesis. This comprehensive volume, which includes discussions of therapeutic strategies that are currently used or under development, is a vital reference for neurobiologists, cell biologists, pathologists, and other scientists pursuing the biological basis of Alzheimer disease, as well as investigators, clinicians, and students interested in its pathogenesis, treatment, and prevention.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Cold Spring Harbor Laboratory Press,U.S.
Date d'édition
2011
Langue
anglais
ISBN 10 
1936113449
ISBN 13 
9781936113446
Reliure
Broché
Numéro d'édition
1
Nombre de pages
520
Éditeur
Selkoe Dennis J, Mandelkow Eckhard, Holtzman David M
Coordonnées du fabricant
non disponible
Personne responsable
non disponible