Protein Synthesis and Translational Control: A Subject Collection from Cold-spring Harbor Perspectives in Biology - Couverture rigide

Hershey, John Wb; Sonenberg, Nahum; Mathews, Michael B

 
9781936113460: Protein Synthesis and Translational Control: A Subject Collection from Cold-spring Harbor Perspectives in Biology
Couverture rigide
ISBN 10 : 1936113465 ISBN 13 : 9781936113460
Editeur : Cold Spring Harbor Laboratory Press,U.S., 2012

Synopsis

The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including "ribosomopathies." Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single-molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high-resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including "ribosomopathies." Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single-molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high-resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Cold Spring Harbor Laboratory Press,U.S.
Date d'édition
2012
Langue
anglais
ISBN 10 
1936113465
ISBN 13 
9781936113460
Reliure
Relié
Nombre de pages
352
Coordonnées du fabricant
Buchpark GmbH
https://www.buchpark.de

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Trebbin
Brandenburg
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Allemagne