DNA Replication: A Subject Collection from Cold Spring Harbor Perspectives in Biology - Couverture rigide

Bell, Stephen D; Mechali, Marcel; Depamphilis, Melvin L

 
9781936113484: DNA Replication: A Subject Collection from Cold Spring Harbor Perspectives in Biology
Couverture rigide
ISBN 10 : 1936113481 ISBN 13 : 9781936113484
Editeur : Cold Spring Harbor Laboratory Press,U.S., 2013

Synopsis

DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass this genetic material on to their descendants. DNA replication involves the coordinated interplay and regulation of many complex protein assemblies during the various stages of cell division. When these processes go awry, cancer and other diseases can ensue.

Written and edited by experts in the field, this volume covers all aspects of DNA replication and its control across all domains of life. The contributors examine the molecular machinery involved in the assembly of replication origin complexes, the establishment of replication forks, unzipping of the double helix, priming of DNA synthesis, and elongation of daughter strands. Chromatin organization and dynamics, lagging-strand maturation, telomere replication, and mechanisms to handle errors and damage in DNA are also discussed.

Including examination of the complex interactions between the core replication machinery and the regulatory circuits that drive cell cycle progression, this volume is an indispensable reference for not only biochemists and molecular biologists, but also cell biologists and all who want to understand this fundamental process of life.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Présentation de l'éditeur

DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass this genetic material on to their descendants. DNA replication involves the coordinated interplay and regulation of many complex protein assemblies during the various stages of cell division. When these processes go awry, cancer and other diseases can ensue.

Written and edited by experts in the field, this volume covers all aspects of DNA replication and its control across all domains of life. The contributors examine the molecular machinery involved in the assembly of replication origin complexes, the establishment of replication forks, unzipping of the double helix, priming of DNA synthesis, and elongation of daughter strands. Chromatin organization and dynamics, lagging-strand maturation, telomere replication, and mechanisms to handle errors and damage in DNA are also discussed.

Including examination of the complex interactions between the core replication machinery and the regulatory circuits that drive cell cycle progression, this volume is an indispensable reference for not only biochemists and molecular biologists, but also cell biologists and all who want to understand this fundamental process of life.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Cold Spring Harbor Laboratory Press,U.S.
Date d'édition
2013
Langue
anglais
ISBN 10 
1936113481
ISBN 13 
9781936113484
Reliure
Relié
Nombre de pages
576
Coordonnées du fabricant
non disponible
Personne responsable
non disponible