Protein–protein interaction of Rv0148 with Htdy and its predicted role towards drug resistance in Mycobacterium tuberculosis: Functional role of ... and drug resistance in M. tuberculosis - Couverture souple

Bhargavi, Gunapati; Hassan, Sameer; Balaji, Subramaniam; Palaniyandi, Kannan

 
9781952751981: Protein–protein interaction of Rv0148 with Htdy and its predicted role towards drug resistance in Mycobacterium tuberculosis: Functional role of ... and drug resistance in M. tuberculosis
Couverture souple
ISBN 10 : 1952751985 ISBN 13 : 9781952751981
Editeur : Eliva Press, 2020

Synopsis

Mycobacterium tuberculosis resides inside host macrophages during infection and adapts to resilient stresses generated by the host immune system. As a response, M. tuberculosis codes for short-chain dehydrogenases/ reductases (SDRs). These SDRs are nicotinamide adenine dinucleotide-reliant oxidoreductases involved in cell homeostasis. The precise function of oxidoreductases in bacteria especially M. tuberculosis were not fully explored. In this study, for the first time, we attempted to predict the functional role of one of the hypothetical oxidoreductase Rv0148 of M. tuberculosis. Overall, the study suggested that Rv0148, though a non-essential gene, is functionally involved in drug resistance and is interconnected with other drug-resistance genes. The absence of Rv0148 displays its prominent role in host immunity.

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Éditeur
Eliva Press
Date d'édition
2020
Langue
anglais
ISBN 10 
1952751985
ISBN 13 
9781952751981
Reliure
Broché
Nombre de pages
38
Coordonnées du fabricant
non disponible
Personne responsable
non disponible