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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins - Couverture souple

Ferraz De Paiva, Raphael Enoque

 
9783030131500: Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
Couverture souple
ISBN 10 : 3030131505 ISBN 13 : 9783030131500
Editeur : Springer, 2019

Synopsis

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

Éditeur
Springer
Date d'édition
2019
Langue
anglais
ISBN 10 
3030131505
ISBN 13 
9783030131500
Reliure
Broché
Nombre de pages
192
Coordonnées du fabricant
ProductSafety@springernature.com
ProductSafety@springernature.com

Poststr. 9
Darmstadt
64293
Allemagne

Autres éditions populaires du même titre

9783030008529: Gold I,iii Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Edition présentée

ISBN 10 :  3030008525 ISBN 13 :  9783030008529
Editeur : Springer Nature Switzerland AG, 2018
Couverture rigide