The DNA, Rna, and Histone Methylomes - Couverture souple

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9783030147945: The DNA, Rna, and Histone Methylomes

Synopsis

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.

Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylatenucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.

This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.


Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de l?auteur

Prof. Dr. hab. Stefan Jurga,

Adam Mickiewicz University, Nanobiomedical Center,

Poznań, Poland

stjurga@amu.edu.pl

Prof. Dr.hab Jan Barciszewski,

Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Poznań, Poland and

Adam Mickiewicz University, Nanobiomedical Center, Poznań, Poland

jan.barciszewski@ibch.poznan.pl

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Autres éditions populaires du même titre

9783030147914: The DNA, Rna, and Histone Methylomes

Edition présentée

ISBN 10 :  3030147916 ISBN 13 :  9783030147914
Editeur : Springer Nature Switzerland AG, 2019
Couverture rigide