The Mast Cell: A Multifunctional Effector Cell - Couverture souple

Ribatti, Domenico

Couverture souple

ISBN 10 : 3030241920 ISBN 13 : 9783030241926

Editeur : Springer Nature Switzerland AG, 2020

Synopsis

Mast cells (MC) are phylogenetically old cells which are distributed throughout the human organism. MC are found in almost all of the major organs and tissues of the body, particularly in association with connective tissue structures such as blood vessels, lymphatic vessels and nerves, and in proximity to surfaces that interface the external environment, such as those of the respiratory and gastrointestinal system and the skin. This selective accumulation at tissue sites where foreign material attempts to invade the host suggests that MC are among the first cells to initiate defensive mechanisms. MC have long been recognized as key cells of type I hypersensitivity reactions. Several lines of evidence, however, indicate that they not only express critical effector functions in classic IgE-associated allergic disorders, but also play important roles in host defense against parasites, bacteria and perhaps even viruses. Indeed, it is now clear that MC can contribute to host defense in thecontext of either acquired or innate immune responses through the release of a myriad of pro-inflammatory and immunoregulatory molecules and the expression of a wide spectrum of surface receptors for cytokines and chemokines. Moreover, there is growing evidence that MC exert distinct non-immunological functions, playing a relevant role in tissue homeostasis, remodeling and fibrosis as well as in the processes of tissue angiogenesis.

A propos du livre

À propos de l?auteur

The author, Domenico Ribatti, Full professor of the University of Bari, is an expert in the field of Mast Cells with more than 800 publications.

Détails de l'édition

• Éditeur: Springer Nature Switzerland AG
• Date d'édition: 2020
• Langue: anglais
• ISBN 10: 3030241920
• ISBN 13: 9783030241926
• Reliure: Broché
• Nombre de pages: 119
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne