Cancer: The Enemy from Within : A Comprehensive Textbook of Cancer's Causes, Complexities and Consequences - Couverture souple
Synopsis
1. The nature and origins of cancer
Cancer as a family of diseases coming from normal cells using normal cell traits in abnormal ways
Cancer as a developmental processOrganization / taxonomy of the neoplasias/ terminology
2. Principles of cancer initiation, promotion and progression
Mutation, growth, clonal heterogeneity
Principles of cancer pathology: form and function and deviation from normal
Key concepts of invasion and metastasis
3. Behavioral hallmarks of cancer
Key behavioral traits that allow cancer cells to outcompete normal cells
Molecular basis of these key behaviors
Cancer as an evolutionary systemCaner as a complex adaptive system
4. History of cancer - how did we get here?
Transformative discoveries
Major advances in cancer biology, etiology, and treatment - foundations for current thinking and present day practice
5. Who gets cancer and why?
Cancer epidemiology worldwide
Causal risk factors
Non-causal risk factors
6. Screening
Why do it?
What does it take?
What works and what are the recommendations?7. Diagnosis and Assessment
Detection and diagnosis
Classification: type, grade, stage, molecular features
Prognostic factors, predictive factors and treatment planning
8. Localized treatment of cancer
Principles and types of oncologic surgery
Principles and types of radiation therapyOther ablative therapies
9. Systemic therapy
Cytotoxic drugs
Hormonal therapies
Targeted therapies
Immunotherapies: (+CAR-T genetic engineering) current reality, future vision
Therapy as selective pressure and the emergence of resistance
Principles of therapy: efficacy, toxicity; cost-benefit
10. End of Life Issues: Personal and Medical
Palliative care: what it is and how it is used
Overuse of therapy at end of life
Hard decisions: when to stop treatment
11. Development of new cancer therapies: evolution and revolution
The ethical, economic, and scientific aspects of translational cancer research
Regulatory requirements
The evolution of clinical trials
Cancer and the law: Right to Die; Right to try
Cancer as big business
Economics of cancer care delivery: Who pays and for what? Who decides?
Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.
