Translational Pancreatic Cancer Research: From Understanding of Mechanisms to Novel Clinical Trials - Couverture rigide

Couverture rigide

ISBN 10 : 3030494756 ISBN 13 : 9783030494759

Editeur : Springer Nature Switzerland AG, 2020

Synopsis

​This book incorporates a multi-disciplinary approach to present how research results can be translated into clinical trials. The first part begins with a chapter on variants of pancreatic cancer, precursor lesions and groups of people at risk to developing the disease. There is a particular focus on intraductal papillary mucinous neoplasia as a large-scale clinical challenge in pancreatology. The next two parts focus on diagnosis, biomarkers and stratification that emphasize how various approaches to biomarker development are important as both prognostic and predictive tools. The final part consists of personalized treatment approaches that include preclinical models of pancreatic cancer and stromal, epigenetic and metabolism targeting as promising approaches to be translated into early phase clinical trials. Chapters within this part also deal with approaches that are close to being implemented in clinical practice or are already being tested in (early) clinical trials, such asthose that targeting the immune systems and strategies to overcome immunotherapy resistance; phase 1 clinical trials and translational approaches in surgical treatment.
Written by experts in their fields, Translational Pancreatic Cancer Research provides an outlook towards future directions by integrating information both from basic and clinical research and though demonstrating pathways to better understanding pancreatic cancer and current approaches to translating these into clinical practice.

A propos du livre

À propos de l?auteur

Christoph W. Michalski
Department of Visceral, Vascular und Endocrine Surgery
University Hospital Halle (Saale)
Halle (Saale), Germany
Jonas Rosendahl
Department of Internal Medicine I
University Hospital Halle (Saale)
Halle (Saale), Germany
Patrick Michl
Department of Internal Medicine I
University Hospital Halle (Saale)
Halle (Saale), Germany
Jörg Kleeff
Department of Visceral, Vascular und Endocrine Surgery
University Hospital Halle (Saale)
Halle (Saale), Germany

Détails de l'édition

• Éditeur: Springer Nature Switzerland AG
• Date d'édition: 2020
• Langue: anglais
• ISBN 10: 3030494756
• ISBN 13: 9783030494759
• Reliure: Relié
• Nombre de pages: 257
• Éditeur: Michalski Christoph W., Rosendahl Jonas, Michl Patrick, Kleeff Jörg
• Coordonnées du fabricant: ProductSafety@springernature.com; ProductSafety@springernature.com; ; Poststr. 9; Darmstadt; 64293; Allemagne