Tumor Suppressor Par-4: Structural Features, Molecular Mechanisms and Function - Couverture rigide

 
9783030735715: Tumor Suppressor Par-4: Structural Features, Molecular Mechanisms and Function
Couverture rigide
ISBN 10 : 3030735710 ISBN 13 : 9783030735715
Editeur : Springer Nature Switzerland AG, 2022

Synopsis

Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar's laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule's structural features, key functional domains, regulation and relevant basic and clinical/translational facets.

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À propos de l?auteur

​Vivek M. Rangnekar, Ph.D. is Professor and Alfred Cohen Chair in Oncology Research in the Department of Radiation Medicine and Associate Director of the Markey Cancer Center at the University of Kentucky. His laboratory studies the molecular cross-talk between oncogenes and tumor suppressor genes in an effort to tilt the balance in favor of tumor suppressor function. Dr. Rangnekar originally discovered and identified the tumor suppressor protein Par-4/PAWR in 1993.

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Éditeur
Springer Nature Switzerland AG
Date d'édition
2022
Langue
anglais
ISBN 10 
3030735710
ISBN 13 
9783030735715
Reliure
Relié
Numéro d'édition
1
Nombre de pages
333
Éditeur
Rangnekar Vivek M.
Coordonnées du fabricant
Springer Nature Customer Service Center GmbH
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Heidelberg
69115
Allemagne

Autres éditions populaires du même titre

9783030735739: Tumor Suppressor Par-4: Structural Features, Molecular Mechanisms and Function

Edition présentée

ISBN 10 :  3030735737 ISBN 13 :  9783030735739
Editeur : Springer, 2022
Couverture souple