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Thymus Transcriptome and Cell Biology (eng)

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ISBN 10 : 3031779207 ISBN 13 : 9783031779206

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Thymus Transcriptome and Cell Biology

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Angola 1:1,400,000 incl. Cabinda Travel Map, waterproof, GPS-compatible, REISE

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ISBN 10 : 3031779207 ISBN 13 : 9783031779206

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Thymus Transcriptome and Cell Biology

Geraldo A. Passos

Edit� par Springer, Springer M�r 2025, 2025

ISBN 10 : 3031779207 ISBN 13 : 9783031779206

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Buch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance.The thymus gland is a lymphoid organ implicated in T cells' maturation, differentiation, and selection. Its function isassociated with the control of immune homeostasis in the body, establishing central immune tolerance, and preventing the onset of autoimmune diseases.This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene. Chapters also explore the mutations in the Aire gene, manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. This new edition includes two new chapters devoted to the genome editing of the Aire gene through Crispr-Cas9 system, and thymic involution.All chapters have been updated to reflect the latest research in the field. 348 pp. Englisch. N� de r�f. du vendeur 9783031779206

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Angola 1:1,400,000 incl. Cabinda Travel Map, waterproof, GPS-compatible, REISE

Passos, Geraldo A.

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ISBN 10 : 3031779207 ISBN 13 : 9783031779206

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Thymus Transcriptome and Cell Biology

Geraldo A. Passos

Edit� par Springer, Springer M�r 2025, 2025

ISBN 10 : 3031779207 ISBN 13 : 9783031779206

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Buch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -This volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance. The thymus gland is a lymphoid organ implicated in T cells' maturation, differentiation, and selection. Its function is associated with the control of immune homeostasis in the body, establishing central immune tolerance, and preventing the onset of autoimmune diseases.This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene. Chapters also explore the mutations in the Aire gene, manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. This new edition includes two new chapters devoted to the genome editing of the Aire gene through Crispr-Cas9 system, and thymic involution.All chapters have been updated to reflect the latest research in the field.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 348 pp. Englisch. N� de r�f. du vendeur 9783031779206

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Thymus Transcriptome and Cell Biology

Geraldo A. Passos

Edit� par Springer, Springer, 2025

ISBN 10 : 3031779207 ISBN 13 : 9783031779206

Neuf Couverture rigide

Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne

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Buch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - This volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance.The thymus gland is a lymphoid organ implicated in T cells' maturation, differentiation, and selection. Its function isassociated with the control of immune homeostasis in the body, establishing central immune tolerance, and preventing the onset of autoimmune diseases.This book focuses on thymus development, their cellular components and their respective function, and the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus and the Autoimmune regulator (Aire) gene. Chapters also explore the mutations in the Aire gene, manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. This new edition includes two new chapters devoted to the genome editing of the Aire gene through Crispr-Cas9 system, and thymic involution.All chapters have been updated to reflect the latest research in the field. N� de r�f. du vendeur 9783031779206

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