The Diels–Alder Reaction as a Key Step in Natural Product Synthesis - Couverture rigide

Couverture rigide

ISBN 10 : 3032099005 ISBN 13 : 9783032099006

Editeur : Springer Nature Switzerland AG, 2026

Synopsis

This volume explores the Diels–Alder reaction, a cornerstone of organic chemistry, tracing its evolution from a classical synthesis tool to a versatile platform for constructing complex molecular architectures. It highlights the reactions historical significance, methodological advancements, and pivotal role in natural product synthesis. From its discovery in the early 20th century, the Diels–Alder reaction revolutionized organic synthesis by enabling efficient formation of six-membered rings with remarkable stereoselectivity and regioselectivity. Over the decades, innovations such as asymmetric catalysis, organocatalysis, and inverse-electron-demand variants have expanded its scope, allowing precise synthesis of highly functionalized frameworks. The volume delves into biomimetic applications, showcasing how the reaction emulates biosynthesis pathways, bridging chemical synthesis and natural product biogenesis. It also examines the groundbreaking discovery of Diels–Alderases, enzymes that catalyze pericyclic reactions in Nature, offering insights into biosynthesis and biocatalysis. Through detailed case studies, the volume illustrates the reactions strategic importance in tackling synthesis challenges posed by intricate natural products. Looking ahead, the volume discusses emerging applications in sustainable chemistry, photochemical activation, and enzyme engineering, emphasizing the adaptability and enduring relevance of this reaction. By integrating modern computational tools and cross-coupling strategies, the Diels–Alder reaction continues to inspire innovation, solidifying its place as a cornerstone of chemical synthesis and retrosynthesis planning.

Détails de l'édition

• Éditeur: Springer Nature Switzerland AG
• Date d'édition: 2026
• Langue: anglais
• ISBN 10: 3032099005
• ISBN 13: 9783032099006
• Reliure: Relié
• Nombre de pages: 277
• Éditeur: Kinghorn A. Douglas, Falk Heinz, Gibbons Simon, Asakawa Yoshinori, Liu Ji-Kai, Dirsch Verena M.
• Coordonnées du fabricant: GPSR Kontakt; ProductSafety@springernature.com; ; Slevogtstraße 3-5; Heidelberg; 69126; Allemagne