Articles liés à Gamma-Glutamyl Transpeptidases: Structure and Function

Gamma-Glutamyl Transpeptidases: Structure and Function - Couverture souple

Livre 8 sur 25: SpringerBriefs in Biochemistry and Molecular Biology

Castellano, Immacolata; Merlino, Antonello

 
9783034806817: Gamma-Glutamyl Transpeptidases: Structure and Function
Couverture souple
ISBN 10 : 3034806817 ISBN 13 : 9783034806817
Editeur : Springer, 2013

Synopsis

Gamma-Glutamyl Transpeptidases (?-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the ?-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released ?-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). ?-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.?-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of ?-GTs and gives information about applications of ?-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.?

Les informations fournies dans la section « Synopsis » peuvent faire référence à une autre édition de ce titre.

À propos de la quatrième de couverture

Gamma-Glutamyl Transpeptidases (¿-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the ¿-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released ¿-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). ¿-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.¿-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson¿s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of ¿-GTs and gives information about applications of ¿-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.¿

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Springer
Date d'édition
2013
Langue
anglais
ISBN 10 
3034806817
ISBN 13 
9783034806817
Reliure
Broché
Nombre de pages
57
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