Airways Smooth Muscle: Development, and Regulation of Contractility: Development and Regulation of Contractility - Couverture souple

9783034874106: Airways Smooth Muscle: Development, and Regulation of Contractility: Development and Regulation of Contractility

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ISBN 10 : 3034874103 ISBN 13 : 9783034874106

Editeur : Birkh�user, 2012

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Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser- vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur- ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites? ii) What determines the density and pattern of inner- vation at reaching the effector? iii) How do the nerves survive and maintain their position once established? iv) What factors influence neurochemical differentiation such that genetically multipotential neu- rones are triggered to synthesize one or combinations of neurotransmit- ters? v) What influence do nerves have on the structure, function and receptor expression of their effector cells? vi) How do diseases interrupt these processes? - see [1].

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�diteurBirkh�user
Date d'�dition2012
ISBN 10 3034874103
ISBN 13 9783034874106
ReliureBroch�
Langueanglais
Nombre de pages436
�diteurRaeburn David, Giembycz Mark A.
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9783764350116: Airways Smooth Muscle: Development, and Regulation of Contractility

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ISBN 10 : 3764350113 ISBN 13 : 9783764350116
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Airways Smooth Muscle: Development, and Regulation of Contractility

David Raeburn

Edit� par Springer, Basel, Birkh�user Basel, Birkh�user Jun 2012, 2012

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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites ii) What determines the density and pattern of inner vation at reaching the effector iii) How do the nerves survive and maintain their position once established iv) What factors influence neurochemical differentiation such that genetically multipotential neu rones are triggered to synthesize one or combinations of neurotransmit ters v) What influence do nerves have on the structure, function and receptor expression of their effector cells vi) How do diseases interrupt these processes - see [1]. 424 pp. Englisch. N� de r�f. du vendeur 9783034874106

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Airways Smooth Muscle: Development, and Regulation of Contractility

Raeburn, David|Giembycz, Mark A.

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Airways Smooth Muscle: Development, and Regulation of Contractility : Development and Regulation of Contractility

Mark A. Giembycz

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ISBN 10 : 3034874103 ISBN 13 : 9783034874106

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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites ii) What determines the density and pattern of inner vation at reaching the effector iii) How do the nerves survive and maintain their position once established iv) What factors influence neurochemical differentiation such that genetically multipotential neu rones are triggered to synthesize one or combinations of neurotransmit ters v) What influence do nerves have on the structure, function and receptor expression of their effector cells vi) How do diseases interrupt these processes - see [1]. N� de r�f. du vendeur 9783034874106

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Airways Smooth Muscle: Development, and Regulation of Contractility

Mark A. Giembycz

Edit� par Birkh�user Basel, Birkh�user Basel Jun 2012, 2012

ISBN 10 : 3034874103 ISBN 13 : 9783034874106

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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -Most studies on autonomic innervation of smooth muscle have focused on the short-term mechanisms involved in neurotransmission in physiological and pathophysiological conditions. However recent obser vations of the long-term plasticity of this system, i. e. its capacity for regeneration and for compensatory change in pattern of innervation and expression of cotransmitters and receptors in ageing, following surgery, trauma or in disease, have indicated that an understanding of the mechanisms involved could influence the design of therapeutic regimes. There is increasing evidence for long-term communication between nerves and smooth muscle cells during development and throughout adult life. To date, the trophic interactions between nerves and airway musculature have attracted little interest, consequently, much of the information presented here is drawn from studies using other smooth muscles. However, the questions posed about trophic interactions dur ing development apply as much to airways smooth muscle neuroeffector systems as to other autonomic neuroeffector systems. These are: i) How do developing nerve fibres know where to go and how do they reach their target sites ii) What determines the density and pattern of inner vation at reaching the effector iii) How do the nerves survive and maintain their position once established iv) What factors influence neurochemical differentiation such that genetically multipotential neu rones are triggered to synthesize one or combinations of neurotransmit ters v) What influence do nerves have on the structure, function and receptor expression of their effector cells vi) How do diseases interrupt these processes - see [1].Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 436 pp. Englisch. N� de r�f. du vendeur 9783034874106

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