This topical insight in the role of cytokines in joint inflammation and destruction helps to better understand key processes in diseases such as rheumatoid arthritis and osteoarthritis. Apart from the impact of cytokines on joint tissues, various chapters address targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay, and mechanisms of cartilage destruction and bone erosion. New information on the cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay and an outline of the role of established cytokines, such as TNF, IL-1 and IL-6, is provided. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.
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Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology. 312 pp. Englisch. N° de réf. du vendeur 9783034896092
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Taschenbuch. Etat : Neu. Cytokines and Joint Injury | Wim B. Van Den Berg (u. a.) | Taschenbuch | Progress in Inflammation Research | xi | Englisch | 2012 | Birkhäuser | EAN 9783034896092 | Verantwortliche Person für die EU: Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin, juergen[dot]hartmann[at]springer[dot]com | Anbieter: preigu. N° de réf. du vendeur 105706106
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Taschenbuch. Etat : Neu. This item is printed on demand - Print on Demand Titel. Neuware -This topical insight in the role of cytokines in joint inflammation and destruction helps to better understand key processes in diseases such as rheumatoid arthritis and osteoarthritis. Apart from the impact of cytokines on joint tissues, various chapters address targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Special attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay, and mechanisms of cartilage destruction and bone erosion. New information on the cytokines IL-15, IL-17 and IL-18 and their position in the complex cytokine interplay and an outline of the role of established cytokines, such as TNF, IL-1 and IL-6, is provided. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles in joint erosion are highlighted. This volume gives a complete and balanced view on pivotal cytokines and joint pathology for the biomedical and clinical researcher.Springer Nature c/o IBS, Benzstrasse 21, 48619 Heek 312 pp. Englisch. N° de réf. du vendeur 9783034896092
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Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology. N° de réf. du vendeur 9783034896092
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