Protein Adsorption and Conformational Changes - Couverture rigide

Couverture rigide

ISBN 10 : 3036526919 ISBN 13 : 9783036526911

Editeur : Mdpi AG, 2022

Synopsis

Protein adsorption to solids, nanomaterials, and biological surfaces is of central interest in many fields, including biomedicine, bioanalytical chemistry, materials engineering, bio-nanotechnology, and basic biomolecular research. Although protein adsorption may sometimes occur with little consequence on molecular structure, interactions with surfaces frequently cause changes in local or global conformations and dynamics, perturbations to secondary structures or tertiary folds, eventually resulting in dramatically altered protein function. Importantly, surfaces may trigger protein misfolding and self-aggregation, or, conversely, promote protein structure formation. The use of nanoscale surfaces to remodel the conformational landscape and the aggregation pathways of amyloidogenic peptides and proteins has been proposed as a promising strategy against several severe human diseases. The rapid growth of applications and technological innovation which is based on or concerned with protein adsorption necessitates renewed efforts to provide molecular-level insights into adsorption-induced protein structural perturbations. In this Special Issue, we gathered the recent findings of experimental and computational investigations that contributed novel insights into protein adsorption with a focus on the structural and dynamic aspects of proteins.

Détails de l'édition

• Éditeur: Mdpi AG
• Date d'édition: 2022
• Langue: anglais
• ISBN 10: 3036526919
• ISBN 13: 9783036526911
• Reliure: Relié
• Nombre de pages: 100
• Éditeur: Assfalg Michael
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible