Impaired Mitochondrial Bioenergetics under Pathological Conditions - Couverture rigide

Couverture rigide

ISBN 10 : 3036546480 ISBN 13 : 9783036546483

Editeur : Mdpi AG, 2022

Synopsis

Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. Finally, studies on the impaired mitochondrial bioenergetics in pathology could provide molecular tools to counteract diseases associated with mitochondrial dysfunction.

Détails de l'édition

• Éditeur: Mdpi AG
• Date d'édition: 2022
• Langue: anglais
• ISBN 10: 3036546480
• ISBN 13: 9783036546483
• Reliure: Relié
• Nombre de pages: 462
• Éditeur: Nesci Salvatore, Lenaz Giorgio
• Coordonnées du fabricant: non disponible
• Personne responsable: non disponible