Nanoparticles in Ocular Drug Delivery Systems - Couverture rigide

Couverture rigide

ISBN 10 : 3036580034 ISBN 13 : 9783036580036

Editeur : Mdpi AG, 2023

Synopsis

Conventional ophthalmic formulations lack prolonged drug release effects and mucoadhesive properties, decreasing their residence time in the precorneal area and, therefore, in drug penetration across ocular tissues, presenting a low bioavailability with a consequent reduction in the therapeutic efficacy. These limitations are related to the physiological mechanisms of the eye, for example, the diluting effect of formulations exerted by the tear fluid, constant turnover of the tear fluid, blink reflex, limited capacity of the conjunctival sac, and drainage of formulations applied by gravity.

To increase the residence time of formulations on the surface of ocular tissues and increase their ability to penetrate these tissues, different strategies can be used, namely, the use of viscosifying agents, mucoadhesive polymers, stimuli-responsive polymers, microparticles, and colloidal carriers (e.g., micelles, liposomes, nanosuspensions, nanoemulsions, polymeric, and lipid nanoparticles). This Special Issue combines the latest research and review works reporting the use of nanoparticles in ophthalmic formulations to increase their bioavailability and improve the therapeutic efficacy of ophthalmic formulations.

Détails de l'édition

• Éditeur: Mdpi AG
• Date d'édition: 2023
• Langue: anglais
• ISBN 10: 3036580034
• ISBN 13: 9783036580036
• Reliure: Relié
• Nombre de pages: 266
• Éditeur: Almeida Hugo, Silva Ana Catarina
• Coordonnées du fabricant: non disponible
• Personne responsable: Buchpark GmbH; gpsr@buchpark.de; ; Krügerweg 1; Trebbin; Brandenburg; 14959; Allemagne