Peptide and Protein Interaction With Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery - Couverture rigide

Bobone, Sara

 
9783319064338: Peptide and Protein Interaction With Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery
Couverture rigide
ISBN 10 : 3319064339 ISBN 13 : 9783319064338
Editeur : Springer International Publishing AG, 2014

Synopsis

In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nano devices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs.

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À propos de l?auteur

I received my M.Sc. Degree in Chemistry magna cum laude from the University of Rome "Sapienza". After the degree, I moved to Tor Vergata, where I won a fellowship for PhD students in Chemical Sciences, under the supervision of Prof. L. Stella. I defended my thesis in 2013 and then continued my work as a postdoctoral fellow. The thesis was awarded the 2012-2013 "Premio Semerano" by the Italian Chemical Society, as the best Italian PhD Physical Chemistry Thesis. The thesis work led to the publication of 7 papers on international journals and to the participation to 13 international and national conferences.

Les informations fournies dans la section « A propos du livre » peuvent faire référence à une autre édition de ce titre.

Éditeur
Springer International Publishing AG
Date d'édition
2014
Langue
anglais
ISBN 10 
3319064339
ISBN 13 
9783319064338
Reliure
Relié
Nombre de pages
153
Coordonnées du fabricant
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Autres éditions populaires du même titre

9783319382739: Peptide and Protein Interaction with Membrane Systems: Applications to Antimicrobial Therapy and Protein Drug Delivery

Edition présentée

ISBN 10 :  331938273X ISBN 13 :  9783319382739
Editeur : Springer, 2016
Couverture souple