Synopsis
Discovery of leptin and elucidation of leptin gene expression.- Leptin receptors and mechanism of action.- Leptin interaction with brain orexigenic and anorexigenic pathways.- Measurement of circulating leptin and soluble leptin receptors.- Physiological and hormonal factors that influence leptin production.- Leptin, obesity and leptin resistance.- Leptin and intermediary metabolism: Focus on glucoregulation and lipid metabolism.- Leptin in acute stress.- Leptin and the kidney.- Leptin, immune function, and inflammation.- Leptin and bone.- Leptin, cell cycle, and cancer.- Leptin, the autonomic nervous system, and hypertension.- Dynamic leptin secretion in obesity and diabetes.- Leptin therapy of congenital leptin deficiency.- Leptin therapy in people with normal leptin gene.- Leptin therapy in patients with lipodystrophy and syndromic insulin resistance.- Leptin therapy in women with hypothalamic amenorrhea.- Leptin therapy as a substitute for insulin replacement in experimental models of diabetes: Clinical implications in humans.- Novel combinatorial therapies involving leptin: Opportunities for mechanistic advances and therapeutic translation in human diseases.
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